E. Andersson

Anabolic sensitivity in healthy, lean, older men is associated with higher expression of amino acid sensors and mTORC1 activators

This study shows that lean, healthy older men maintain anabolic sensitivity to amino acids and exercise, with increased mTORC1 signaling and muscle protein synthesis, suggesting aging alone does not cause anabolic resistance.

Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

The paper uses phage-based screening to identify 1,712 virus-host interactions mimicking host short linear motifs, revealing therapeutic targets for broad-spectrum antivirals.

The dynamic properties of a nuclear coactivator binding domain are evolutionarily conserved

The paper compares the dynamic properties of an ancient NCBD from a bilaterian ancestor to human NCBD, finding conserved dynamics despite increased thermodynamic stability.

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities

The paper identifies coronavirus-host protein interaction motifs, revealing SARS-CoV-2 specific mechanisms and a peptide-based inhibitor that blocks infection.

Proteome-scale amino-acid resolution footprinting of protein-binding sites in the intrinsically disordered regions of the human proteome

The paper introduces HD2, a proteome-scale method for identifying and characterizing SLiM-mediated protein interactions with amino acid resolution, and provides tools for analyzing the results.

Evolution of an interaction between disordered proteins resulted in increased heterogeneity of the binding transition state

The paper compares the binding transition states of ancestral and human IDP domains, finding increased heterogeneity in the human complex.

Helix formation during the coupled binding and folding of intrinsically disordered proteins monitored by synchrotron-radiation circular dichroism spectroscopy

The paper uses synchrotron-radiation circular dichroism to study helix formation during the binding of intrinsically disordered proteins, revealing kinetic phases and structural intermediates.