M. Damme

MFSD1 in complex with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes

The paper identifies MFSD1 as a lysosomal dipeptide uniporter that facilitates the transport of cationic and neutral dipeptides when amino acid exporters are overloaded.

The solute carrier MFSD1 decreases β1 integrins activation status and thus tumor metastasis

This study shows that MFSD1 reduces β1 integrin activation, thereby suppressing tumor metastasis in a mouse model.

AMPylation is a specific lysosomal protein posttranslational modification in neuronal maturation.

The paper identifies AMPylation as a lysosomal posttranslational modification in neuronal maturation and shows it inhibits PLD3 activity.

LAMP3 is critical for surfactant homeostasis in mice

This study shows that LAMP3 is essential for maintaining pulmonary surfactant homeostasis in mice, as its absence leads to altered surfactant composition and lung function.

Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice

The paper identifies thioperamide as a drug that increases lysobisphosphatidic acid (LBPA) levels, reducing cholesterol overload in Niemann-Pick type C cells and mice.