Preclinical validation of a second generation leishmanization vaccine against vector transmitted fatal visceral leishmaniasis
H. L. Nakhasi, R. DEY, S. Gannavaram, S. Karmakar, P. Bhattacharya, N. Ismail, A. Satoskar, G. Volpedo, L. F. Oliveira, J. Oristian, C. Meneses, J. G. Valenzuela, S. Kamhawi, W. W. Zhang, G. Matlashewski, , K. Pandey
This study evaluates the protective efficacy of a CRISPR-edited Leishmania major strain against visceral leishmaniasis in hamsters and shows it induces a pro-inflammatory immune response and prevents disease.
bioRxiv · Nov 18, 2020Immunology