The paper identifies alternative splicing of IFITM genes in Chinese horseshoe bats, producing two isoforms with differential antiviral activities against influenza and coronaviruses.

bioRxiv · Dec 4, 2023 · PreprintMicrobiology

Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses

A. Banerjee, N. El-Sayes, P. Budylowski, D. Richard, H. Maan, J. Aguiar, K. Baid, M. R. D'Agostino, J. C. Ang, B. J.- M. Tremblay, S. Afkhami, M. Karimzadeh, A. T. Irving, L. Yip, M. A. Ostrowski, , K. Mossman

This study shows SARS-CoV-2 infection induces a mild type I IFN response in vitro and in moderate COVID-19 cases, and cannot inhibit exogenous IFN induction.

bioRxiv · Jun 18, 2020Immunology

Unique Evolution of Antiviral Tetherin in Bats

J. A. Hayward, M. Tachedjian, A. Johnson, A. T. Irving, T. B. Gordon, J. Cui, A. Nicolas, I. Smith, V. Boyd, G. A. Marsh, M. L. Baker, L.-F. Wang, G. Tachedjian

This study characterizes the evolution of tetherin in bats, identifying unique structural variants and splice isoforms with antiviral functions.

bioRxiv · Apr 8, 2020Evolutionary Biology