Author

Sarah R. Murphy

Nanostring Technologies (United States)Primary ORCID profile (0009-0005-1296-6325 · 3 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Sarah R. MurphyiD3 papers · Icahn School of Medicine at Mount Sinai

Biology Disciplines

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Cancer Biology· 1 Genomics· 1 Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 3 Organism:human· 3 Assay:spatial transcriptomics· 3 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Assay:proteomics· 2 Research Focus:spatial domain detection· 2 Approach:statistical model· 2

Frequent Co-Authors

Mark GregoryiD· 2 shared Yan LiangiD· 2 shared Aïcha BenTaiebiD· 1 shared Alec J. WalkeriD· 1 shared Alicia C. Walker· 1 shared Alma AnderssoniD· 1 shared Alsu M. MissarovaiD· 1 shared Ananya MavinkurveiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

Mark GregoryORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Spatial Decoding of Tertiary Lymphoid Structure Maturation in Non-Small Cell Lung Cancer Using Deep Neural Networks

Bob Chen, Conrad Foo, Alma Andersson, Brandon D. Kayser, Yiming Yang, Alsu M. Missarova, Priyanka Kulkarni, Jan-Christian Huetter, Sharmila Chatterjee, Youngmi J. Kim, Yan Liang, Emily Killinbeck, Sarah R. Murphy, Eloisa Fuentes, Jennifer Margaret Giltnane, , Lisa M. McGinnis

The paper develops a framework to decode TLS maturation in NSCLC using spatial omics data and deep learning, identifying two distinct spatial ecosystems linked to patient outcomes.

bioRxiv · Jan 20, 2026 · PreprintGenomics

Early-life stromal niches orchestrate B lymphopoiesis at the brain's borders

Alec J. Walker, Theodore M. Fisher, Sydney K. Caldwell, Anushree S. Gupte, Justin M. Reimertz, Bristy Sabikunnahar, Samuel E. Marsh, Yvanka de Soysa, Vahid Gazestani, Alicia C. Walker, Youtong Huang, Ananya Mavinkurve, Helena J. Barr, Toby Black Lanser, Sarah R. Murphy, , Beth Stevens

This study identifies the murine dura mater as a transient niche for early-postnatal B lymphopoiesis, highlighting the role of CXCL12-expressing fibroblasts in supporting B cell development.

bioRxiv · Nov 27, 2025 · PreprintImmunology

Integrating 12 Spatial and Single Cell Technologies to Characterise Tumour Neighbourhoods and Cellular Interactions in three Skin Cancer Types

P. Prakrithi, Laura F. Grice, Feng Zhang, Levi Hockey, Samuel X. Tan, Xiao Tan, Zherui Xiong, Onkar Mulay, Andrew Causer, Andrew Newman, Duy Pham, Guiyan Ni, Zewen Kelvin Tuong, Xinnan Jin, Eun Ju Kim, , Quan Hoang Nguyen

The paper integrates 12 spatial and single-cell technologies to analyze cellular interactions and signatures in three skin cancers, identifying key therapeutic targets and genetic associations.

bioRxiv · Jul 25, 2025 · PreprintCancer Biology

High-resolution molecular atlas of a lung tumor in 3D

Tancredi Massimo Pentimalli, Simon Schallenberg, Daniel León-Periñán, Ivano Legnini, Ilan Theurillat, Gwendolin Thomas, Anastasiya Boltengagen, Sonja Fritzsche, Jose Nimo, Lukas Ruff, Gabriel Dernbach, Philipp Sebastian Jurmeister, Sarah R. Murphy, Mark Gregory, Yan Liang, , Nikolaus Rajewsky

This paper presents a 3D spatial atlas of a human lung carcinoma, revealing tumor microenvironment niches and their associated immune interactions and survival outcomes.

bioRxiv · May 10, 2023 · PreprintSystems Biology