Structure-specific Mini-Prion Model for Alzheimer's Disease Tau Fibrils
Vishnu Vijay, Gregory E. Merz, Karen Tsay, Andrew P. Longhini, Samuel Lobo, Athena Quddus, K. Nakagawa, Michael P. Vigers, Arthur A. Melo, Eric Tse, Shea Joan-Emma, M. Scott Shell, K S Kosik, Daniel R. Southworth, Songi Han
The paper designs synthetic tau fibrils that mimic AD and CTE structures, showing strong seeding ability and catalytic effects in vitro and in cells.
Alzheimer s & Dementia · Dec 1, 2025Peer-reviewedBiophysics