Margaret R. Starostik

Gene duplication of SNAPC1 generates transcription factors for snRNAs and sex-specific piRNAs

The paper identifies SNPC-1.2 as a female-specific piRNA transcription factor in C. elegans, revealing how gene duplication and functional specialization generate sex-specific piRNA expression.

FOXO/DAF-16 modulates the transcription factor ROR/NHR-23 and inhibits the let-7 microRNA to maintain multipotency during dauer

This study identifies DAF-16/FOXO's role in repressing let-7 microRNA and NHR-23 to maintain multipotency during dauer in C. elegans.

Common variation in meiosis genes shapes human recombination phenotypes and aneuploidy risk

The paper identifies genetic variants in meiosis genes associated with recombination phenotypes and aneuploidy risk using preimplantation genetic testing data.

Drosophila Males Use 5'-to-3' Phased Biogenesis to Make Stellate-silencing piRNAs that Lack Homology to Maternally Deposited piRNA Guides

The paper shows that Drosophila males produce Su(Ste) piRNAs through 5'-to-3' phased biogenesis triggered by maternally deposited piRNAs, and this process is bypassed when mothers are XXY.

Expression and subcellular localization of USH1C/harmonin in the human retina provide insights into pathomechanisms and therapy

The paper investigates harmonin expression and localization in human retinas to understand USH1C pathophysiology and potential gene therapy approaches.

daf-16/FOXO blocks adult cell fate in Caenorhabditis elegans dauer larvae via lin-41/TRIM71

This study shows that daf-16/FOXO promotes multipotency in C. elegans dauer larvae by upregulating lin-41/TRIM71, which blocks premature adult cell fate markers.

SNPC-1.3 is a sex-specific transcription factor that drives male piRNA expression in C. elegans

The paper identifies SNPC-1.3 as a male-specific transcription factor that regulates piRNA expression in C. elegans and shows its sex-specific regulation by TRA-1.

Single-cell analysis of human embryos reveals diverse patterns of aneuploidy and mosaicism

The paper analyzes single-cell RNA sequencing data from human embryos to quantify aneuploidy and mosaicism, finding widespread mosaic aneuploidies in 80% of embryos.