Author

B. Adhikari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1 Ecology· 1 Immunology· 1 Microbiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Approach:statistical model· 4 Research Focus:drug response / drug discovery· 3 Research Focus:ecology & biodiversity· 2 Organism:human· 2 Organism:plant (other)· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Adhikari· 2 shared C. Sotriffer· 2 shared E. Wolf· 2 shared M. Diebold· 2 shared A. Bastola· 1 shared A. Doelle· 1 shared A. Knapp· 1 shared A. Kraemer· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

A. Adhikari

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Author profile →

8 papers

Recent·Most cited

Identification of Suitable Target/E3 Ligase Pairs for PROTAC Development using a Rapamycin-induced Proximity Assay (RiPA)

B. Adhikari, K. Schneider, M. Diebold, C. Sotriffer, E. Wolf

This paper introduces a rapamycin-induced proximity assay (RiPA) to identify effective E3 ligase-target pairs for PROTAC development, demonstrating its ability to predict degradation capabilities.

eLife · Dec 6, 2024Peer-reviewedBiochemistry

Extraction and characterization of cellulose from invasive weeds from central Nepal: A potential prospect of environmental management.

S. Dhakal, A. Tiwari, A. Adhikari, S. K. Shrestha, B. Adhikari

This study extracts and characterizes cellulose from invasive weeds in Nepal, showing it can be used as a sustainable alternative to plastics and textiles.

bioRxiv · Sep 8, 2022 · PreprintBiochemistry

Computational modeling of macrophage iron sequestration during host defense against Aspergillus

B. Adhikari, Y. Scindia, L. Sordo Vieira, H. de Assis Lopes Ribeiro, J. Masison, N. Yang, L. Fonseca, M. Wheeler, A. Knapp, Y. Mei, B. Helba, C. Atkinson, W. Schroeder, B. Mehrad, R. Laubenbacher

The paper develops a computational model of macrophage iron sequestration during Aspergillus infection, showing that transferrin receptor-1 upregulation precedes inflammatory cytokine induction.

bioRxiv · Jan 24, 2022Immunology

Design, Synthesis and Evaluation of WD-repeat containing protein 5 (WDR5) degraders

A. Doelle, B. Adhikari, A. Kraemer, J. Weckesser, N. Berner, L.-M. Berger, M. Diebold, M. Szewczyk, D. Barsyte-Lovejoy, C. Arrowsmith, J. Gerbel, F. Loehr, V. Doetsch, M. Eilers, S. Heinzlmeir, , S. Knapp

This study designs, synthesizes, and evaluates two series of WDR5 degraders, showing that linker length and nature affect degradation efficacy.

bioRxiv · Apr 12, 2021 · PreprintCancer Biology

CONCENTRATION OF THIOUREA IS EFFECTIVE IN BREAKING THE DORMANCY OF POTATO VARIETIES.

S. Ranabhat, M. Dhital, R. Subedi, A. Adhikari, B. Adhikari, S. Shrestha

This paper tests Thiourea concentrations on potato dormancy breaking and sprouting, finding 1% effective for Desiree and 3% for Cardinal.

bioRxiv · Dec 2, 2020 · PreprintPlant Biology

Epidemiology of Dengue viral infection in Nepal: 2006-2019

K. R. Rijal, B. Adhikari, B. Ghimire, B. Dhungel, U. R. Pyakurel, P. Shah, A. Bastola, M. R. Banjara, B. D. Pandey, D. M. Parker, P. Ghimire

This study analyzes dengue incidence trends and spatio-temporal patterns in Nepal from 2006-2019, finding increased risk in lowland regions and rising spread to mid-mountains.

bioRxiv · Aug 27, 2020 · PreprintMicrobiology

In Silico Analysis of Secondary Metabolites that Modulates Enzymes of Cholesterol Target

R. Marahatha, S. Basnet, B. R. Bhattarai, P. Budhathoki, B. Aryal, B. Adhikari, G. Lamichhane, D. K. Poudel, N. Parajuli

This paper identifies sixteen secondary metabolites with inhibitory activity against XO and HMGR through in-silico analysis, showing potential as drug candidates for hypercholesterolemia treatment.

bioRxiv · Jul 24, 2020 · PreprintBiochemistry

Forest canopy resists plant invasions: a case study of Chromolaena odorata in sub-tropical Sal (Shorea robusta) forests of Nepal

L. N. Sharma, B. Adhikari, M. F. Watson, B. Karna, E. Paudel, B. B. Shrestha, D. P. Rijal

This study examines the factors influencing the spread of Chromolaena odorata in Sal forests, finding that canopy cover significantly reduces its presence.

bioRxiv · Aug 28, 2019 · PreprintEcology