B. F. Haynes

The paper identifies Fab-dimerized glycan-reactive antibodies in HIV-infected macaques and HIV-naïve humans that neutralize HIV-1 and can be elicited by vaccination.

The paper shows glycans on SARS-CoV-2 Spike influence RBD conformational states, affecting antibody neutralization and vaccine design.

The paper analyzes SARS-CoV-2 spike protein conformations and develops engineered constructs to control its mobility for vaccine design.

This study evaluates an SIV-based IDLV vaccine expressing sequential CH505 Envs in rhesus macaques, showing improved antibody responses and virus control but no broadly neutralizing antibodies.

This paper develops a conditional expression strategy to enable mature B cell expression of bnAb precursors in transgenic mice, overcoming developmental blocks caused by bnAb properties.

This study evaluates whether maternal HIV Env vaccination boosts autologous virus neutralization in HIV-infected pregnant women, finding no significant enhancement in neutralization potency.

This study identifies a critical role for W571 in HIV-1 Env allostery by showing mutations disrupting CD4-induced rearrangements and rendering Env insensitive to CD4 binding.

This study examines the effect of HLA-B -21M dimorphism on NK cell diversity and function in HIV-1/HCMV co-infected African individuals, finding no significant correlation with HLA-E abundance or functional advantage.

The paper shows that boosting RV144 vaccine recipients with ALVAC-HIV and AIDSVAX B/E increases C1C2-specific antibody-dependent cellular cytotoxicity breadth and potency.

The paper describes the structure of a chimpanzee SIV Env trimer and shows it induces HIV V2-specific neutralizing antibodies in mice.

This study uses single-cell methods to analyze HIV latency, finding that host transcriptional profiles correlate with proviral activity levels in infected cells.

The paper identifies improbable mutations critical for HIV broadly neutralizing antibody development and proposes a mutation-guided vaccine strategy.