Differences in signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide
P. Pickford, M. Lucey, Z. Fang, S. Bitsi, J. Broichhagen, D. Hodson, J. Minnion, G. A. Rutter, S. R. Bloom, A. Tomas, B. Jones
This study compares the signalling, trafficking, and glucoregulatory effects of exendin-4 and lixisenatide, finding differences in cAMP signalling potency and receptor recycling that impact glucose control.
bioRxiv · Oct 16, 2019Pharmacology & Toxicology