G. Nouailles

Neural Network-Assisted Humanization of COVID-19 Hamster scRNAseq Data Reveals Matching Severity States in Human Disease

This paper uses neural networks to match disease states between human and hamster COVID-19 scRNAseq data, finding similar cellular responses in specific cell types across species.

Single-cell-resolved interspecies comparison identifies a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19

The paper compares single-cell RNA-seq data from hamster and human COVID-19 samples to identify a shared inflammatory axis and a neutrophil-endothelial program associated with severe disease.

IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota

This study shows IL-33 reduces IL-22 production in innate lymphoid cells, increasing resistance to Streptococcus pneumoniae infection, and links genetic variation in IL-33 signaling to human pneumonia.

A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants

This study compares immune responses and efficacy of different SARS-CoV-2 vaccines in hamsters, finding that a live-attenuated vaccine provides superior protection against variants.

In contrast to TH2-biased approaches, TH1 COVID-19 vaccines protect Syrian hamsters from severe disease in the absence of dexamethasone-treatable vaccine-associated enhanced respiratory pathology

This study compares TH1 and TH2-biased vaccines in Syrian hamsters, showing that TH1 vaccines prevent severe disease without inducing VAERD, while TH2 vaccines cause VAERD through eosinophil recruitment and TH2 cytokine upregulation.

Longitudinal omics in Syrian hamsters integrated with human data unravel complexity of moderate immune responses to SARS-CoV-2

The paper integrates longitudinal omics data from Syrian hamsters with human data to understand immune responses to SARS-CoV-2, identifying key cellular and molecular mechanisms.