Author

M. Witzenrath

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 7 Research Focus:host-pathogen & immune response· 6 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:proteomics· 3 Assay:scRNA-seq· 3

Frequent Co-Authors

G. Nouailles· 5 shared J. Trimpert· 5 shared A. D. Gruber· 4 shared C. Goffinet· 4 shared E. Wyler· 4 shared F. Pott· 4 shared L. E. Sander· 4 shared M. Landthaler· 4 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

G. Nouailles

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Neural Network-Assisted Humanization of COVID-19 Hamster scRNAseq Data Reveals Matching Severity States in Human Disease

V. D. Friedrich, P. Pennitz, E. Wyler, J. M. Adler, D. Postmus, L. G. T. Alves, J. Prigann, F. Pott, D. Vladimirova, T. Hoefler, C. Goekeri, M. Landthaler, C. Goffinet, A.-E. Saliba, M. Scholz, , G. Nouailles

This paper uses neural networks to match disease states between human and hamster COVID-19 scRNAseq data, finding similar cellular responses in specific cell types across species.

bioRxiv · Jan 11, 2024 · PreprintImmunology

Single-cell-resolved interspecies comparison identifies a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19

S. Peidli, G. Nouailles, E. Wyler, J. M. Adler, S. Kunder, A. Voss, J. Kazmierski, F. Pott, P. Pennitz, D. Postmus, L. G. Teixeira Alves, C. Goffinet, A. D. Gruber, N. Bluethgen, M. Witzenrath, , S. D. Praktiknjo

The paper compares single-cell RNA-seq data from hamster and human COVID-19 samples to identify a shared inflammatory axis and a neutrophil-endothelial program associated with severe disease.

bioRxiv · Aug 25, 2023Immunology

IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota

I. Roewekamp, L. Maschirow, A. Rabes, F. Fiocca Vernengo, G. A. Heinz, M.-F. Mashreghi, S. Caesar, M. Milek, A. Fagundes, S.-M. Wienhold, G. Nouailles, L. Yao, D. Bruder, J. Boehme, M. Puzianowska-Kuznicka, , B. Opitz

This study shows IL-33 reduces IL-22 production in innate lymphoid cells, increasing resistance to Streptococcus pneumoniae infection, and links genetic variation in IL-33 signaling to human pneumonia.

bioRxiv · Jul 19, 2023Immunology

A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants

G. Nouailles, J. M. Adler, P. Pennitz, S. Peidli, G. Teixeira Alves, M. Baumgart, J. Bushe, A. Voss, A. Langenhagen, F. Pott, J. Kazmierski, C. Goekeri, S. Simmons, N. Xing, C. Langner, , J. Trimpert

This study compares immune responses and efficacy of different SARS-CoV-2 vaccines in hamsters, finding that a live-attenuated vaccine provides superior protection against variants.

bioRxiv · May 16, 2022Immunology

Altered fibrin clot structure contributes to thrombosis risk in severe COVID-19

M. Wygrecka, A. Birnhuber, B. Seeliger, L. Michalick, O. Pak, A.-S. Schultz, F. Schramm, M. Zacharias, G. Gorkiewicz, S. David, T. Welte, J. J. Schmidt, N. Weissmann, R. T. Schermuly, G. Barreto, , K. T. Preissner

The paper shows that altered fibrin clot structure in severe COVID-19 patients contributes to thrombosis risk by forming compact, fibrinolysis-resistant clots.

bioRxiv · Sep 17, 2021Biochemistry

A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae

P. M. Kaplonek, L. Yao, K. Reppe, F. M. Voss, T. Kohler, F. Ebner, A. Schaefer, U. Blohm, P. Priegue, M. Brautigam, C. L. Pereira, S. G. Parameswarappa, M. Emmadi, P. Menova, M. Witzenrath, , P. H. Seeberger

This paper develops a synthetic glycoconjugate vaccine that combines pneumococcal proteins with a defined oligosaccharide to provide broad protection against multiple serotypes of Streptococcus pneumoniae in animal models.

bioRxiv · Jul 29, 2021Immunology

Longitudinal omics in Syrian hamsters integrated with human data unravel complexity of moderate immune responses to SARS-CoV-2

G. Nouailles, E. Wyler, P. Pennitz, D. Postmus, D. Vladimirova, J. Kazmierski, F. Pott, K. Dietert, M. Mülleder, V. Farztdinov, B. Obermayer, S.-M. Wienhold, S. Andreotti, T. Höfler, B. Sawitzki, , M. Witzenrath

The paper integrates longitudinal omics data from Syrian hamsters with human data to understand immune responses to SARS-CoV-2, identifying key cellular and molecular mechanisms.

bioRxiv · Dec 18, 2020Immunology

A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model

J. Kreye, S. M. Reincke, H.-C. Kornau, E. Sanchez-Sendin, V. M. Corman, H. Liu, M. Yuan, N. C. Wu, X. Zhu, C.-C. D. Lee, J. Trimpert, M. Hoeltje, K. Dietert, L. Stoeffler, N. von Wardenburg, , N. Osterrieder

This study identifies a potent SARS-CoV-2 neutralizing antibody that protects hamsters from infection and lung damage.

bioRxiv · Aug 15, 2020Immunology