Author

Bahar Zirak

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Hani GoodarziiD· 4 shared Vijay RamaniiD· 2 shared Ajay V. MakeriD· 1 shared Albertas NavickasiD· 1 shared Alejandro Sweet-CorderoiD· 1 shared Ali Saberi· 1 shared Ali Sharifi‐ZarchiiD· 1 shared Amirhossein Zarezadeh· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersGenomics

Hani GoodarziORCID

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4 papers

Recent·Most cited

The adaptive architecture of tRNA dependencies across physiological tumor environments

Siyu Chen, Trey Charbonneau, Kian Yousefi, Bahar Zirak, Sean Lee, Tanvi Joshi, April Pawluk, Vijay Ramani, Hani Goodarzi

The paper maps tRNA dependencies in cancer cells across different environments, finding that tRNA dependencies are environmentally sensitive while some dependencies are shared across cell lines.

bioRxiv · Oct 9, 2026 · PreprintGenomics

Targeting Osteosarcoma heterogeneity to improve therapeutic response

Brenda Melano, Truc Dinh, Bahar Zirak, Brian J Woo, Man Hung Choi, Mehran Karimzadeh, Hani Goodarzi, Alejandro Sweet-Cordero

The paper identifies transcription factors that drive osteosarcoma cell states and shows that modulating them can increase sensitivity to targeted therapy.

bioRxiv · Jan 2, 2025 · PreprintGenomics

Macrophages redeploy functional cancer cell surface proteins following phagocytosis

Regan F. Volk, Sara E. Casebeer, Andrew C Condon, Bahar Zirak, Nayelis A. Manon, Iryna Irkliyenko, Huajun Liao, Tao Shao, Tommaso Pollini, Vijay Ramani, Ajay V. Maker, Trevor P. Fidler, Hani Goodarzi, Balyn W. Zaro

This study shows that macrophages transfer intact cancer cell surface proteins to their own surface after phagocytosis, which may affect their function and metabolism.

bioRxiv · Sep 23, 2024 · PreprintImmunology

Revealing the Grammar of Small RNA Secretion Using Interpretable Machine Learning

Bahar Zirak, Mohsen Naghipourfar, Ali Saberi, Delaram Pouyabahar, Amirhossein Zarezadeh, Lixi Luo, Lisa Fish, Doowon Huh, Albertas Navickas, Ali Sharifi‐Zarchi, Hani Goodarzi

This study introduces ExoGRU, a machine learning model that predicts small RNA secretion from sequence, identifies key RNA-binding proteins, and develops exoCLIP to map RNA interactomes in extracellular vesicles.

Cell Genomics · Mar 8, 2024Peer-reviewedSystems Biology