A role for protease activated receptor type 3 (PAR3) in nociception demonstrated through development of a novel peptide agonist
Juliet M. Mwirigi, Moeno Kume, Shayne N. Hassler, Ayesha Ahmad, Pradipta R. Ray, Changyu Jiang, Alexander G. Chamessian, Nakleh Mseeh, Breya P. Ludwig, Benjamin D. Rivera, Marvin T. Nieman, Thomas Van de Ven, Ru‐Rong Ji, Gregory O. Dussor, Scott A. Boitano, , Theodore John Price
The paper develops a PAR3 agonist and shows it induces mechanical hypersensitivity in mice, suggesting PAR3's role in nociception and plasticity.
Journal of Pain · Jan 12, 2021Peer-reviewedNeuroscience