C. Benz

Characterization of novel and essential kinetoplast-associated proteins in Trypanosoma brucei

This paper identifies and characterizes novel kinetoplast-associated proteins in Trypanosoma brucei, revealing their essential roles in mitochondrial DNA replication, segregation, and cell cycle regulation.

Functional differentiation of Sec13 paralogs in the euglenozoan protists

The paper identifies two Sec13 paralogs in Euglenozoa and shows they have distinct functional roles in COPII, NPC, and SEA/GATOR complexes.

A syntenin inhibitor blocks endosomal entry of SARS-CoV-2 and a panel of RNA viruses

A syntenin inhibitor blocks endosomal entry of SARS-CoV-2 and multiple RNA viruses by preventing their uptake through receptor-mediated endocytosis.

Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

The paper uses phage-based screening to identify 1,712 virus-host interactions mimicking host short linear motifs, revealing therapeutic targets for broad-spectrum antivirals.

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities

The paper identifies coronavirus-host protein interaction motifs, revealing SARS-CoV-2 specific mechanisms and a peptide-based inhibitor that blocks infection.

Proteome-scale amino-acid resolution footprinting of protein-binding sites in the intrinsically disordered regions of the human proteome

The paper introduces HD2, a proteome-scale method for identifying and characterizing SLiM-mediated protein interactions with amino acid resolution, and provides tools for analyzing the results.

Phosphoproteomic analysis of mammalian infective Trypanosoma brucei subjected to heat shock suggests atypical mechanisms for thermotolerance

The paper identifies 193 heat shock responsive phosphorylation sites in Trypanosoma brucei but only 20 proteins with significant abundance changes, suggesting phosphorylation, not protein abundance, drives thermotolerance.

Organising the cell cycle in the absence of transcriptional control: Dynamic phosphorylation co-ordinates the Trypanosoma brucei cell cycle post-transcriptionally

This study identifies dynamic phosphorylation as a key regulator of the Trypanosoma brucei cell cycle, revealing its role in coordinating cell cycle progression and post-transcriptional regulation.

Dynamic regulation of the Trypanosoma brucei transferrin receptor in response to iron starvation is mediated via the 3UTR

The paper shows that the 3UTR of TbTfR mediates dynamic regulation of the transferrin receptor in T. brucei under iron starvation, independent of genomic location.