Author

C. Tokheim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. Fu· 2 shared M. Brown· 2 shared X. S. Liu· 2 shared X. Wang· 2 shared A. B. Riemer· 1 shared A. Bernat· 1 shared A. Fortian· 1 shared A. Lazar· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

J. Fu

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Author profile →

4 papers

Recent·Most cited

The spatial landscape of Cancer Hallmarks reveals patterns of tumor ecology

M. Sibai, S. Cervilla, D. Grases, E. Musulen, R. Lazcano, C.-K. Mo, V. Davalos, A. Fortian, M. Romeo, A. Bernat, C. Tokheim, E. Grande, F. Real, J. Barretina, A. Lazar, , E. Porta-Pardo

The paper uses spatial transcriptomics to analyze Cancer Hallmarks in 63 tumors, revealing spatial patterns of hallmark activity and interdependencies between cancer and tumor microenvironment.

bioRxiv · Jun 18, 2022Cancer Biology

Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor Alpha

A. Sahu, X. Wang, P. Munson, J. Klomp, X. Wang, S. Gu, G. Qian, P. Nicol, Z. Zeng, C. Wang, C. Tokheim, W. Zhang, J. Fu, J. Wang, N. Nair, , K. Flaherty

BipotentR identifies immune-metabolic regulators for bipotent anticancer drugs, demonstrating ESRRA inhibition's effects on tumor metabolism and immune mechanisms.

bioRxiv · Oct 25, 2021 · PreprintCancer Biology

In Vivo CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer Immunotherapy Target

X. Wang, C. Tokheim, B. Wang, S. S. Gu, Q. Tang, Y. Li, N. Traugh, Y. Zhang, Z. W. Li, B. Zhang, J. Fu, T. Xiao, W. Li, C. A. Meyer, J. Chu, , X. S. Liu

The paper identifies Cop1 as a modulator of macrophage infiltration and cancer immunotherapy in TNBC by using in vivo CRISPR screens and multi-omics analyses.

bioRxiv · Dec 9, 2020Cancer Biology

High-throughput prediction of MHC Class I and Class II neoantigens with MHCnuggets

X. M. Shao, R. Bhattacharya, J. Huang, I. K. A. Sivakumar, C. Tokheim, L. Zheng, D. HIrsch, B. Kaminow, A. Omdahl, M. Bonsack, A. B. Riemer, V. Velculescu, V. Anagnostou, K. Pagel, R. Karchin

The paper introduces MHCnuggets, a deep learning method for predicting MHC class I and II neoantigen binding, showing improved performance and scalability across 26 cancer types.

bioRxiv · Oct 4, 2019Immunology