Author

C.-J. Guo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 8 Microbiology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 12 Research Focus:protein folding & dynamics· 4 Research Focus:protein structure prediction· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:structural biology· 3 Assay:cryo-EM· 2 Organism:Drosophila· 2

Frequent Co-Authors

J.-L. Liu· 9 shared J. Zhong· 6 shared X. Zhou· 6 shared T. Zhang· 4 shared B. Yin· 3 shared C.-C. Chang· 3 shared G.-M. Lu· 3 shared H.-H. Hu· 3 shared

Activity by Year

2018-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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9 shared papersBiochemistry

J.-L. Liu

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

Filamentation and inhibition of prokaryotic CTP synthase

C.-J. Guo, Z.-X. Wang, J.-L. Liu

This study determines the structure of E. coli CTPS filament and identifies regulatory mechanisms, revealing a solvent-accessible ammonia tunnel and distinct CTP binding mode.

bioRxiv · Oct 19, 2023 · PreprintBiochemistry

Dynamic atP5CS2 Filament Facilitates Substrate Channeling

C.-J. Guo, T. Zhang, Q. Leng, X. Zhou, J. Zhong, J.-L. Liu

This study identifies a filament structure in Arabidopsis thaliana P5CS2 that facilitates substrate channeling, enhancing catalytic efficiency in proline synthesis under abiotic stress.

bioRxiv · Sep 7, 2023 · PreprintBiochemistry

Functional characterization of helminth-associated Clostridiales reveals covariates of Treg differentiation

S. Sargsian, A. Lejeune, D. Ercelen, W.-B. Jin, A. Varghese, P. Loke, Y. A. L. Lim, C.-J. Guo, K. Cadwell

The paper characterizes functional properties of helminth-associated Clostridiales bacteria and identifies their role in promoting Treg differentiation and Trichuris egg hatching.

bioRxiv · Jun 5, 2023Microbiology

Structural basis for activation of glutaminase

C.-J. Guo, Z.-X. Wang, J.-L. Liu

This paper determines the structure of human glutaminase with phosphate, revealing an allosteric activation mechanism and showing phosphate antagonizes known inhibitors.

bioRxiv · Mar 30, 2023 · PreprintBiochemistry

Structural basis of bifunctional CTP/dCTP synthase

C.-J. Guo, Z. Zhang, J. Zhong, J.-L. Liu

This study determines the structure of CTP/dCTP synthase bound to deoxynucleotides, revealing its bifunctional mechanism and cellular compartmentation potential.

bioRxiv · Feb 19, 2023Biochemistry

Gut bacteria-derived serotonin promotes immune tolerance in early life

K. Z. Sanidad, S. L. Rager, H. C. Carrow, A. Ananthanarayanan, R. Callaghan, P. Ravisankar, T. Li, A. R. Savage, J. A. Brown, M. Amir, R. Luo, F. Mardorsky Rowdo, M. L. Martin, R. B. Silver, D. Artis, , M. Y. Zeng

This study shows that neonatal gut bacteria produce serotonin, which promotes immune tolerance by inhibiting mTOR and increasing regulatory T cells.

bioRxiv · Sep 25, 2022Immunology

GTP cycling gates CTP synthase activation

C.-J. Guo, Y.-F. Wu, S.-Y. Guo, J.-L. Lu, L. Xu, Y. Fu, X. Zhou, J. Zhong, W. Wang, Z. Zhang, J.-L. Liu

This study reveals how GTP cycling gates CTP synthase activation through three sequential checkpoints, linking GTP binding and dissociation to catalytic steps in CTP synthesis.

bioRxiv · Sep 24, 2022 · PreprintBiochemistry

Structural basis of human PRPS2 filaments

G.-M. Lu, H.-H. Hu, C.-C. Chang, J. Zhong, X. Zhou, C.-J. Guo, T. Zhang, Y.-L. Li, B. Yin, J.-L. Liu

This study determines the structure of hPRPS2 polymers using cryo-EM, revealing how ADP binding affects polymerization and catalytic activity.

bioRxiv · Jul 11, 2022 · PreprintBiochemistry

Allosteric inhibition of PRPS is moderated by filamentous polymerization

H. Hu, G.-M. Lu, C.-C. Chang, Y. Li, J. Zhong, C.-J. Guo, X. Zhou, B. Yin, T. Zhang, J.-L. Liu

The paper investigates two filament structures of E. coli PRPS resolved by Cryo-EM, revealing how ligand binding modulates allosteric inhibition and PRPP production.

bioRxiv · Apr 28, 2022Biochemistry

Structural basis of dynamic P5CS filaments

J. Zhong, C.-J. Guo, X. Zhou, C.-C. Chang, B. Yin, T. Zhang, H.-H. Hu, G.-M. Lu, J.-L. Liu

This study determines the structure of Drosophila P5CS filament, revealing how filamentation coordinates GK and GPR domains for catalysis.

bioRxiv · Dec 2, 2021Biochemistry

The proline synthesis enzyme P5CS forms cytoophidia in Drosophila

B. Zhang, O. Y. Tastan, X. Zhou, C.-J. Guo, X. Liu, A. Thind, H.-H. Hu, S. Zhao, J.-L. Liu

The paper identifies P5CS as a CTPS-interacting protein in Drosophila and shows they form cytoophidia, linking two enzymes in pyrimidine and proline biosynthesis.

bioRxiv · Dec 11, 2019Cell Biology

Depletion of microbiome-derived molecules in the host using Clostridium genetics

C.-J. Guo, B. Allen, K. Hiam, D. Dodd, W. van Treuren, S. Higginbottom, C. Fischer, J. Sonnenburg, M. Spitzer, M. Fischbach

This study develops a genetic method to disable Clostridium species and investigates the impact of microbiome-derived molecules on host IgA modulation.

bioRxiv · Aug 27, 2018Microbiology