Author

Sakthivel Ravi

University of FloridaORCID 0000-0002-5159-6030Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Organism:mouse· 4 Assay:imaging· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:spatial domain detection· 2

Frequent Co-Authors

Jose Francisco AbisambraiD· 5 shared Marangelie Criado‐MarreroiD· 4 shared Daylin Barroso· 3 shared Marcelo FeboiD· 3 shared Stefan ProkopiD· 3 shared Christian B. Lessard· 2 shared John KoreniD· 2 shared MacKenzie L. BoleniD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersNeuroscience

Jose Francisco AbisambraORCID

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5 papers

Recent·Most cited

PERK Deficiency Amplifies Molecular, Structural, and Network Vulnerability to Repetitive Mild Traumatic Brain Injury

Marangelie Criado‐Marrero, Sakthivel Ravi, Daylin Barroso, Tristyn N. Garza, Diana Marcela Cuestas Torres, Christian B. Lessard, Juan Pablo Castaño, MacKenzie L. Bolen, Uriel Rubinovich, Stefan Prokop, Paramita Chakrabarty, Laura P.W. Ranum, Marcelo Febo, Jose Francisco Abisambra

This study shows that PERK deficiency worsens molecular, structural, and network damage in mice after repetitive mild traumatic brain injury.

Neurobiology of Disease · Jul 11, 2026Peer-reviewedNeuroscience

Progressive Supranuclear Palsy PERK haplotype B selectively translates DLX1 promoting tau toxicity

Christian B. Lessard, Diego Rubio-Rubio, Samantha G Tolton, Marangelie Criado‐Marrero, Sakthivel Ravi, Tristyn N. Garza, John Koren, Jennifer Phillips, Pritha Bagchi, Karen N. McFarland, Deepak Chhangani, Todd Eliot Golde, Benoit I. Giasson, Jada M. Lewis, Paramita Chakrabarty, , Jose Francisco Abisambra

This study identifies a PERK-B/DLX1 pathway as a novel driver of tau pathology in human PSP and flies, showing DLX1 promotes tau toxicity.

bioRxiv · Jun 30, 2025 · PreprintNeuroscience

Age dictates brain functional connectivity and axonal integrity following repetitive mild traumatic brain injuries

Marangelie Criado‐Marrero, Sakthivel Ravi, Ekta Bhaskar, Daylin Barroso, Michael A. Pizzi, Lakiesha N. Williams, Cheryl Lea Wellington, Marcelo Febo, Jose Francisco Abisambra

This study examines how age affects brain connectivity and white matter integrity after repetitive mild traumatic brain injuries in mice using multimodal imaging techniques.

bioRxiv · Jan 25, 2024 · PreprintNeuroscience

Spatial Metabolome Lipidome and Glycome from a Single brain Section

Harrison A. Clarke, Xin Ma, Cameron J. Shedlock, Terrymar Medina, Tara R. Hawkinson, Lei Wu, Roberto A. Ribas, Shannon B. Keohane, Sakthivel Ravi, Jennifer L. Bizon, Sara N. Burke, Jose Francisco Abisambra, Matthew E. Merritt, Boone M. Prentice, Craig W. Vander Kooi, , Ramon C. Sun

The paper presents a method for simultaneous spatial analysis of metabolome, lipidome, and glycome from a single tissue section using mass spectrometry imaging and a computational framework called Sami.

bioRxiv · Jul 22, 2023 · PreprintSystems Biology

Repetitive mild traumatic brain injury impairs resting state fMRI connectivity and alters protein profile signaling networks

Sakthivel Ravi, Marangelie Criado‐Marrero, Daylin Barroso, Isadora Braga, MacKenzie L. Bolen, Uriel Rubinovich, Gabriela P. Hery, Matteo M. Grudny, John Koren, Stefan Prokop, Marcelo Febo, Jose Francisco Abisambra

This study investigates how repetitive mild traumatic brain injury (rmTBI) affects brain functional connectivity and protein profiles in mice, revealing altered connectivity and inflammatory responses.

bioRxiv · Sep 21, 2022 · PreprintNeuroscience