Author

D. Barbosa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

B. Gini· 2 shared C. Gomez· 2 shared C. M. Blakely· 2 shared D. L. Kerr· 2 shared L. Tan· 2 shared P. Gui· 2 shared V. Olivas· 2 shared W. Wu· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

B. Gini

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CDK4 or CDK6 upregulation induces DNA replication stress and genomic instability to cause EGFR targeted therapy resistance in lung cancer

B. Gini, P. Gui, W. Wu, D. L. Kerr, L. Tan, D. Barbosa, V. Olivas, P. Allegakoen, C. Gomez, P. Halliday, S. Elmes, V. Steri, T. Chakrabarti, T. G. Bivona, C. M. Blakely

This study shows that CDK4/6 upregulation causes DNA replication stress and genomic instability, leading to resistance to EGFR inhibitors in lung cancer, and suggests combining CDK4/6 and EGFR inhibitors as a treatment.

bioRxiv · Mar 12, 2024 · PreprintCancer Biology

Plasmodium falciparum Acetyl-CoA Synthetase is essential for parasite intraerythrocytic development and chromatin modification

I. O. Prata, E. F. Galindo Cubillos, D. Barbosa, J. Martins, J. C. Setubal, G. Wunderlich

This study shows that PfACS is essential for Plasmodium falciparum growth and chromatin regulation, with knockdown or inhibition impairing parasite development and altering histone acetylation.

bioRxiv · Jun 13, 2021Microbiology

Targeted cancer therapy induces APOBEC fuelling the evolution of drug resistance

D. R. Caswell, M. K. Mayekar, P. Gui, E. K. Law, N. I. Vokes, C. M. Ruiz, M. Dietzen, M. Angelova, C. Bailey, O. Pich, B. Bakker, W. Wu, T. J. Humpton, D. L. Kerr, W. Hill, , Argyr

This study shows that targeted cancer therapy induces APOBEC-mediated mutagenesis, promoting drug resistance by increasing genetic diversity through mechanisms involving NF-κB activation and reduced DNA repair.

bioRxiv · Dec 18, 2020Cancer Biology

Dynein-dynactin segregate meiotic chromosomes in C. elegans spermatocytes

D. Barbosa, V. Teixeira, J. Duro, A. Carvalho, R. Gassmann

This study shows that dynein-dynactin are essential for meiotic chromosome segregation in C. elegans spermatocytes, with a mutation causing aneuploidy and developmental defects.

bioRxiv · Oct 19, 2020Cell Biology