M. Irmler

Early body weight gain in TALLYHO/JngJ mice predicts adult diabetic phenotype, mimicking childhood obesity

The paper identifies weaning body weight as a key predictor of adult diabetes in TALLYHO/JngJ mice, highlighting its relevance to childhood obesity research.

Autocrine Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts

The paper identifies Sfrp1 as an autocrine inhibitor of fibroblast invasion during lung fibrosis by analyzing fibroblast states and signaling pathways in mouse lung regeneration.

Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria

This study examines a mouse model of methylmalonic aciduria, finding reduced energy expenditure, altered metabolism, and metabolic inflexibility.

A novel stem cell type at the basal side of the subventricular zone maintains adult neurogenesis

The paper identifies a novel basal NSC population in the subventricular zone that contributes to adult neurogenesis, distinct from apical NSCs in molecular and functional properties.

Specific induction of double negative B cells during protective and pathogenic immune responses

The paper identifies double negative B cells as an inducible population expanded in inflammatory diseases and vaccine responses, showing clonal expansion and antigen-specific antibody production.

A mosaic renal myeloid subtype with T-cell inhibitory and protumoral features is linked to immune escape and survival in clear cell renal cell cancer

The paper identifies a renal myeloid subtype in clear cell renal cell cancer that exhibits immunoinhibitory and tumor-promoting features, correlates with poor patient survival, and suggests therapeutic targets.