Author

S. Bobbala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 5 Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Assay:proteomics· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

E. A. Scott· 7 shared M. Frey· 4 shared N. B. Karabin· 3 shared M. Vincent· 2 shared S. Allen· 2 shared S. Yi· 2 shared T. Stack· 2 shared A. Golding· 1 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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7 shared papersBioengineering

E. A. Scott

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Intratumoral administration of mRNA-1273 vaccine delays melanoma growth in mice

D. T. Boehm, K. M. Landreth, E. Sen-Kilic, K. S. Lee, B. Misra, S. Bobbala, F. H. Damron, T. W. Liu

This study shows that intratumoral mRNA-1273 vaccine injections delay melanoma growth in mice by increasing CD8+ T cell infiltration and enhancing immune checkpoint therapy responses.

bioRxiv · May 6, 2024 · PreprintImmunology

Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells

E. Morgun, J. Zhu, S. Almunif, S. Bobbala, M. S. Aguilar, J. Wang, K. Conner, Y. Cui, L. Cao, C. Seshadri, E. A. Scott, C.-R. Wang

This study shows that vaccinating with mycobacterial lipid-loaded nanoparticles induces persistent lipid antigen presence and memory T cell differentiation in mice.

bioRxiv · Mar 7, 2023Immunology

Shaping neonatal immunization by tuning delivery of synergistic adjuvants via nanocarriers

S. Barman, F. Borriello, B. Brook, C. Pietrasanta, M. De Leon, C. Sweitzer, M. Menon, S. D. van Haren, D. Soni, Y. Saito, E. Nanishi, S. Yi, S. Bobbala, O. Levy, E. A. Scott, D. J. Dowling

This study identifies synergistic adjuvants for neonatal immunization using nanocarriers, showing enhanced Th1 bias and humoral responses in mice.

bioRxiv · Jun 3, 2022Immunology

Targeted Delivery of Chloroquine to Plasmacytoid Dendritic Cells Enhances Inhibition of the Type I Interferon Response

M. E. Allen, A. Golding, V. Rus, N. B. Karabin, S. Li, C. Lescott, S. Bobbala, E. A. Scott, G. L. Szeto

This study shows that delivering chloroquine via nanocarriers specifically to plasmacytoid dendritic cells reduces type I interferon production in SLE models.

ACS Biomaterials Science & Engineering · Nov 23, 2021Peer-reviewedBioengineering

Subcutaneous nanotherapy repurposes the immunosuppressive mechanism of rapamycin to enhance allogeneic islet graft viability

J. Burke, X. Zhang, S. Bobbala, M. Frey, C. Fuentes, H. Haddad, S. Allen, R. Richardson, G. Ameer, E. A. Scott

This paper shows subcutaneous rapamycin delivery via nanocarriers changes its immunosuppressive mechanism, improving islet graft survival in a transplant model.

bioRxiv · Sep 3, 2020Bioengineering

The Combination of Morphology and Surface Chemistry Defines the Biological Identity of Nanocarriers in Human Blood

E. A. Scott, N. B. Karabin, M. Vincent, S. Allen, S. Bobbala, M. Frey, S. Yi, Y. Yang

The paper shows that both the surface chemistry and morphology of nanocarriers influence their protein corona composition and immune interactions in human blood.

bioRxiv · Sep 2, 2020Bioengineering

Co-administration of macropinocytosis inhibitory nanoparticles (MiNP) for enhanced nanoparticle circulation time and target tissue accumulation following subcutaneous injection

T. Stack, Y.-G. Liu, M. Frey, S. Bobbala, M. Vincent, E. A. Scott

This paper shows that co-injecting macropinocytosis inhibitory nanoparticles (MiNP) with targeted nanoparticles improves their circulation time and tissue accumulation after subcutaneous injection.

bioRxiv · Aug 26, 2020Bioengineering

Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets

M. P. Vincent, S. Bobbala, N. B. Karabin, M. Frey, Y. Liu, J. O. Navidzadeh, T. Stack, E. A. Scott

This study shows that nanocarrier surface chemistry can stabilize or denature adsorbed albumin, affecting macrophage clearance through SR-A1 receptor recognition.

bioRxiv · Apr 24, 2020Bioengineering