Author

D. K. Shoemark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1

Frequent Co-Authors

A. D. Davidson· 3 shared R. B. Sessions· 3 shared A. J. Mulholland· 2 shared B. Simonetti· 2 shared J. L. Daly· 2 shared K. Klein· 2 shared L. Simon-Gracia· 2 shared P. J. Cullen· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

A. D. Davidson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Molecular dynamics of spike variants in the locked conformation: RBD interfaces, fatty acid binding and furin cleavage sites.

D. K. Shoemark, A. F. Oliveira, A. D. Davidson, I. Berger, C. Schaffitzel, A. J. Mulholland

This study uses molecular dynamics simulations to analyze sequence variations in SARS-CoV-2 spike proteins and their effects on receptor binding domain interfaces, fatty acid binding, and furin cleavage site motions across variants.

bioRxiv · May 6, 2022 · PreprintBiochemistry

ESCPE-1 Mediates Retrograde Endosomal Sorting of the SARS-CoV-2 Host Factor Neuropilin-1

B. Simonetti, J. L. Daly, L. Simon-Gracia, K. Klein, S. Weeratunga, C. Anton-Plagaro, A. Tobi, L. Hodgson, P. Lewis, K. J. Heesom, D. K. Shoemark, A. D. Davidson, B. M. Collins, T. Teesalu, Y. Yamauchi, P. J. Cullen

The paper identifies Neuropilin-1 as a retrograde cargo of ESCPE-1 and shows ESCPE-1 mediates its trafficking, potentially facilitating SARS-CoV-2 infection.

bioRxiv · Jan 20, 2022Cell Biology

Identification and Validation of Novel Microtubule Suppressors with an Imidazopyridine Scaffold through Structure Based Virtual Screening and Docking.

S. A. Elseginy, A. S. F. Oliveira, D. K. Shoemark, R. B. Sessions

This paper identifies and validates a novel imidazopyridine scaffold as a microtubule inhibitor through virtual screening and docking, showing antiproliferative and apoptotic effects in cancer cells.

bioRxiv · Dec 8, 2021Cancer Biology

Simulations support the interaction of the SARS-CoV-2 spike protein with nicotinic acetylcholine receptors

A. S. Oliveira, A. A. Ibarra, I. Bermudez, L. Casalino, Z. Gaieb, D. K. Shoemark, T. Gallagher, R. B. Sessions, R. E. Amaro, A. J. Mulholland

The paper uses molecular simulations to show that the SARS-CoV-2 spike protein's Y674-R685 loop binds to nicotinic acetylcholine receptors, with specific interactions and conformational changes observed across different receptor subtypes.

bioRxiv · Jul 16, 2020Biochemistry

Neuropilin-1 is a host factor for SARS-CoV-2 infection

J. L. Daly, B. Simonetti, C. Anton Plagaro, M. Kavanagh Williamson, D. K. Shoemark, L. Simon-Gracia, K. Klein, M. Bauer, R. Hollandi, U. F. Greber, P. Horvath, R. B. Sessions, A. Helenius, J. A. Hiscox, T. Teesalu, , Y. Yamauchi

This study shows that SARS-CoV-2's S1 protein binds to NRP1 via the CendR motif, enhancing infection and identifying NRP1 as a therapeutic target.

bioRxiv · Jun 5, 2020Cell Biology