Author

Dianne E. Chadwick

Ontario Institute for Cancer Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Steve GallingeriD· 2 shared Adam DowleiD· 1 shared Alexandra Misura· 1 shared Amy Xin Wei ZhangiD· 1 shared Andrew N. HoldingiD· 1 shared August LiniD· 1 shared Ayelet BorgidaiD· 1 shared Benjamin Haibe‐KainsiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Steve GallingerORCID

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Author profile →

3 papers

Recent·Most cited

Aberrant splicing of MBD1 reshapes the epigenome to drive convergent myeloerythroid defects in MDS

He Tian Chen, Pratik Joshi, Séverine Cathelin, Soheil Jahangiri, Saeer A Adeel, Joshua Xu, Emily Tsao, Yulin Mo, David Kealy, Adam Dowle, Zaldy Balde, Marry Xuan, Dylan Gowlett-Park, Katarina Czibere, Alexandra Misura, , Kristin J. Hope

This study identifies MBD1-L, an aberrantly spliced transcript in MDS, which drives epigenetic changes leading to myeloerythroid defects, and shows ASO-based targeting can restore erythroid differentiation.

Blood · Jun 20, 2026Peer-reviewedCancer Biology

Plasma cell-free DNA methylome as early detection and prognostic marker for pancreatic cancer

Sanjeev Budhathoki, Yonathan Brhane, Gordon Fehringer, Shu Yi Shen, Dianne E. Chadwick, Philip C. Zuzarte, Ayelet Borgida, Daniel Diniz De Carvalho, Steve Gallinger, Rayjean J. Hung

This study identifies cell-free DNA methylation markers for early detection and prognosis of pancreatic cancer with high accuracy and survival stratification.

medRxiv · May 29, 2025 · PreprintGenetic & Genomic Medicine

Whole Genomes Define Concordance of Matched Primary, Xenograft, and Organoid Models of Pancreas Cancer

Deena M.A. Gendoo, Robert Edward Denroche, Amy Xin Wei Zhang, Nikolina Radulovich, Gun Ho Jang, Mathieu Lemire, Sandra Elisabeth Fischer, Dianne E. Chadwick, Ilinca M. Lungu, Emin Ibrahimov, Ping‐Jiang Cao, Lincoln David Stein, Julie M. Wilson, John M.S. Bartlett, Ming‐Sound Tsao, , Benjamin Haibe‐Kains

The paper compares whole-genome data from primary pancreatic cancer, xenografts, and organoids to assess genetic concordance across different models.

PLoS Computational Biology · Jan 10, 2019Peer-reviewedBioinformatics