Author

E. F. McCaffrey

Primary ORCID profile (0000-0001-7241-1798 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

E. F. McCaffreyiD1 paper · National Institutes of Health

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:imaging· 3 Research Focus:spatial domain detection· 3 Approach:microscopy & imaging analysis· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

M. Angelo· 3 shared N. F. Greenwald· 3 shared A. Baranski· 2 shared L. Keren· 2 shared S. C. Bendall· 2 shared A. C. Kagel· 1 shared A. Cao· 1 shared A. Delmastro· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersImmunology

M. Angelo

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Single-Cell Imaging Maps Inflammatory Cell Subsets to Pulmonary Arterial Hypertension Vasculopathy

S. Ferrian, A. Cao, E. F. McCaffrey, T. Saito, N. F. Greenwald, M. R. Nicolls, T. Bruce, R. T. Zamanian, P. A. Del Rosario, M. Rabinovitch, M. Angelo

The paper maps immune cell subsets in PAH lungs using MIBI-TOF, identifying mo-DCs and their role in vascular remodeling and linking immune dysregulation to disease severity in HPAH.

bioRxiv · Dec 3, 2022Immunology

Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma

T. Risom, D. R. Glass, C. C. Liu, B. Rivero-Gutierrez, A. Baranski, E. F. McCaffrey, N. F. Greenwald, A. C. Kagel, S. H. Strand, S. Varma, A. Kong, L. Keren, S. Srivastava, C. Zhu, Z. Khair, , M. Angelo

The paper analyzes tumor microenvironment changes from normal to invasive breast cancer using imaging and machine learning, finding coordinated shifts in stromal cell location and function.

bioRxiv · Jan 5, 2021Cancer Biology

Multiplexed imaging of human tuberculosis granulomas uncovers immunoregulatory features conserved across tissue and blood

E. F. McCaffrey, M. Donato, L. Keren, Z. Chen, M. Fitzpatrick, V. Jojic, A. Delmastro, N. F. Greenwald, A. Baranski, W. Graf, M. Bosse, P. K. Ramdial, E. Forgo, D. Van Valen, M. van de Rijn, , M. Angelo

This study uses multiplexed imaging and transcriptomics to identify immunosuppressive features in TB granulomas and blood, linking local and systemic immune responses.

bioRxiv · Jun 8, 2020 · PreprintImmunology