S. C. Bendall

Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells

This study shows autophagy compensates for inflammation-induced metabolic issues in old HSCs, and temporarily boosting autophagy can restore their function.

Unraveling human hematopoietic progenitor cell diversity through association with intrinsic regulatory factors

The paper defines human HSPC subsets and differentiation trajectories using surface proteins and functional regulators, validated by epigenetic analysis and clonal assays.

Gestationally-Dependent Immune Organization at the Maternal-Fetal Interface

This study develops a single-cell framework to analyze immune cell dynamics at the maternal-fetal interface across gestation, revealing gestation-dependent immune profiles and roles of mononuclear phagocytes and neutrophils.

Expression of terminal deoxynucleotidyl transferase (TdT) identifies lymphoid-primed progenitors in human bone marrow

The paper identifies TdT-expressing progenitors in human bone marrow that show lymphoid potential while retaining myeloid capacity, redefining the lympho-myeloid axis.

Magnitude and kinetics of the human immune cell response associated with severe dengue progression by single-cell proteomics

The paper uses single-cell proteomics to analyze immune cell responses in severe dengue patients, identifying distinct immune dynamics compared to uncomplicated dengue.

Reproducible, high-dimensional imaging in archival human tissue by Multiplexed Ion Beam Imaging by Time-of-Flight (MIBI-TOF)

This study validates MIBI-TOF for consistent, high-dimensional imaging in archival human tissue, showing high concordance with single-plex IHC and automated cell population analysis.

The role of antigen recognition in the γδ T cell response at the controlled stage of M. tuberculosis infection.

This study identifies a distinct CD8+γδ T cell population in controlled Mtb infection that exhibits NK-like cytotoxicity and stage-specific antigen recognition.

Human IL-10-producing B cells have diverse states induced from multiple B cell subsets

The paper identifies IL-10-producing B cells as a transient state induced from multiple B cell subsets, with unique enrichment in tolerant liver transplant recipients.

mSWI/SNF interacts with the ribosome and its inhibition/mutations alter translation and sensitize to mTOR/PI3K inhibitors

This study shows mSWI/SNF complexes interact with the ribosome, alter translation, and increase sensitivity to mTOR/PI3K inhibitors in cancer cells with mutations.

Multiplexed Ion Beam Imaging Readout of Single-Cell Immunoblotting

This paper introduces scIB-MIBI-TOF, a method combining single-cell immunoblotting with multiplexed ion beam imaging to detect proteoforms from glioblastoma cells.

Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma

The paper analyzes tumor microenvironment changes from normal to invasive breast cancer using imaging and machine learning, finding coordinated shifts in stromal cell location and function.

Multiplexed imaging of human tuberculosis granulomas uncovers immunoregulatory features conserved across tissue and blood

This study uses multiplexed imaging and transcriptomics to identify immunosuppressive features in TB granulomas and blood, linking local and systemic immune responses.

Multiplexed Single-cell Metabolic Profiles Organize the Spectrum of Human Cytotoxic T Cells

This study maps metabolic profiles of human cytotoxic T cells using single-cell technologies, revealing tissue-specific metabolic states and spatial metabolic neighborhoods in colorectal carcinoma.

An integrated multi-omic single cell atlas to redefine human B cell memory

The paper develops a multi-omic single-cell atlas of human B cells, identifying ten subsets and showing phenotype drives B cell function.

Variation of immune cell responses in humans reveals sex-specific coordinated signaling across cell types

The paper profiles immune cell responses in humans to identify sex-specific signaling patterns and provides reference ranges for immune markers.

Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy

The paper presents a mass cytometry workflow for standardized immune monitoring in immunotherapy trials, identifying immune cell signatures and validating its robustness across samples and centers.