M. Donato

Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans

The paper identifies conserved antiviral pathways across macaques and humans using transcriptomic data from viral infections, showing shared and virus-specific responses that inform pandemic preparedness.

A Compact and Effective Photon-Resolved Image Scanning Microscope

This paper introduces a data-acquisition module for fluorescence LSM that enhances single-photon imaging capabilities, enabling super-resolution and multi-species imaging.

Disease Tolerance Acquired Through Repeated Plasmodium Infection Involves Epigenetic Reprogramming of Innate Immune Cells

The paper shows that repeated Plasmodium infection leads to epigenetic changes in innate immune cells, which suppress inflammation and confer long-term disease tolerance in Ugandan children.

Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection

This study shows that eosinophils migrate to the lungs early after Mycobacterium tuberculosis infection in mice and macaques, mediated by GPR183 and Ch25h, independent of CCR3.

Crosstalk of Histone Modifications in the Healthy Human Immune System

The paper analyzes histone post-translational modifications in human immune cells to uncover their interactions and functional implications.

The BrightEyes-TTM: an Open-Source Time-Tagging Module for Single-Photon Microscopy

The paper introduces an open-source time-tagging module for single-photon microscopy, enabling high-precision temporal tagging and supporting new imaging techniques.

Multiplexed imaging of human tuberculosis granulomas uncovers immunoregulatory features conserved across tissue and blood

This study uses multiplexed imaging and transcriptomics to identify immunosuppressive features in TB granulomas and blood, linking local and systemic immune responses.