M. Rabinovitch

High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension

The paper shows high shear stress induces endothelial-mesenchymal transition and pulmonary arterial hypertension by reducing ERG expression, which can be mitigated by ERG replenishment.

A Computational Growth and Remodeling Framework for Adaptive and Maladaptive Pulmonary Arterial Hemodynamics

This paper develops a computational framework to simulate adaptive and maladaptive pulmonary arterial hemodynamics and identify contributors to PAH phenotypes.

Single-Cell Imaging Maps Inflammatory Cell Subsets to Pulmonary Arterial Hypertension Vasculopathy

The paper maps immune cell subsets in PAH lungs using MIBI-TOF, identifying mo-DCs and their role in vascular remodeling and linking immune dysregulation to disease severity in HPAH.

Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function

This study shows that frataxin deficiency in endothelial cells causes mitochondrial respiration defects and vasoconstriction, contributing to pulmonary hypertension.

Leishmania amazonensis sabotages host cell SUMOylation for intracellular survival

This study identifies SUMOylation inhibition as a mechanism by which Leishmania amazonensis enhances its survival in host macrophages.

Endogenous Retroviral Elements Generate Pathologic Neutrophils and Elastase Rich Exosomes in Pulmonary Arterial Hypertension

The paper shows that endogenous retroviruses contribute to neutrophil dysfunction and exosome-mediated pulmonary arterial hypertension.

Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19

Single-cell multi-omic profiling identifies immune dysregulation in severe COVID-19, including neutrophil hyperactivation and anti-inflammatory monocytes.