Author

S. Best

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:bulk RNA-seq· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

A. Chiramel· 2 shared C. Shaia· 2 shared F. Bouamr· 2 shared F. Feldmann· 2 shared J. Lovaglio· 2 shared K. McNally· 2 shared P. Hanley· 2 shared R. Broeckel· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersMicrobiology

A. Chiramel

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Human ESCRT-I and ALIX function as scaffolding helical filaments in vivo

S. J. Spada, K. M. Rose, P. Sette, S. K. O'Connor, V. B. Dussupt, V. S. Yerramilli, K. Nagashima, V. Helle Sjoelund, P. Cruz, J. Kabat, M. Smelkinson, S. Ganesan, A. Nita-Lazar, S. Scarlata, V. Hirsch, , F. Bouamr

This study shows ESCRT-I and ALIX form helical filaments in vivo, serving as structural scaffolds and ESCRT-III assembly templates for membrane scission and viral budding.

bioRxiv · May 1, 2024 · PreprintCell Biology

The drug disposition in the Spleen: A novel study of CYP and UGT-mediated drug metabolism.

P. Inuwa, S. Paine, S. Best, K. Mosinska-Kodzik, C. Rauch

This study investigates drug metabolism in the spleen using pig models to assess CYP and UGT enzyme activity and their role in drug disposition.

bioRxiv · Apr 17, 2024 · PreprintPharmacology & Toxicology

Lethal COVID-19 Associates With RAAS-Induced Inflammation For Multiple Organ Damage Including Mediastinal Lymph Nodes

J. W. Guarnieri, M. Topper, K. Beigel, J. A. Haltoom, A. Chadburn, J. Frere, J. An, H. Cope, A. Borczuk, S. Sinha, C. Lim, J. Kim, J. Park, C. Meydan, J. Foox, , K Clark

This study identifies non-canonical genes linked to RAAS overactivation in lethal COVID-19, causing multi-organ damage and mediastinal lymph node dysfunction.

bioRxiv · Oct 8, 2023 · PreprintImmunology

Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters

X. Liu, H.-S. Park, Y. Matsuoka, C. Santos, L. Yang, C. Luongo, I. Moore, R. Johnson, N. Garza, P. Zhang, P. Lusso, S. Best, U. Buchholz, C. Le Nouën

This study compares two live-attenuated vaccines in hamsters, showing that B/HPIV3/S-6P induces stronger immune responses and better protection against SARS-CoV-2 variants than B/HPIV3/S-2P.

PLOS Pathogens · Jun 23, 2023Peer-reviewedMicrobiology

Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19

S. Robertson, O. Bedard, K. McNally, C. Shaia, C. Clancy, M. Lewis, R. Broeckel, A. Chiramel, J. G. Shannon, G. Sturdevant, R. Rosenke, S. L. Anzick, E. Forte, C. Preuss, C. Baker, , S. Best

The paper uses genetically diverse mice to model varied innate immune responses to SARS-CoV-2 infection, showing differences in survival, viral replication, and cytokine profiles.

bioRxiv · Sep 17, 2021Microbiology

Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques

E. Speranza, J. N. Purushotham, J. R. Port, B. Schwarz, M. Flagg, B. N. Williamson, F. Feldmann, M. Singh, L. Perez-Perez, G. L. Sturdevant, L. M. Roberts, A. Carmody, J. E. Schulz, N. van Doremalen, A. Okumura, , E. de Wit

This study compares immune dynamics in young and old rhesus macaques infected with SARS-CoV-2, finding age-related differences in post-acute immune responses but similar acute disease outcomes.

bioRxiv · Sep 8, 2021Immunology

A pigtailed macaque model for Kyasanur Forest disease virus and Alkhurma hemorrhagic disease virus

R. Broeckel, F. Feldmann, K. McNally, A. Chiramel, P. Hanley, J. Lovaglio, R. Rosenke, D. Scott, G. Saturday, F. Bouamr, S. Robertson, S. Best

This paper establishes a pigtailed macaque model for KFDV and AHFV that replicates human disease symptoms and viral tropism.

bioRxiv · Jun 1, 2021Microbiology