J. Seoane

IKK1 kinase coordinates BRD4 and JAK/STAT signaling to subvert DNA damage-based anticancer therapy

This study identifies IKK1's role in coordinating BRD4 and JAK/STAT signaling to resist DNA damage-based therapy in colorectal cancer.

Pan-cancer organoid validation of tumor outlier chromosomal amplification events

The paper validates oncogenic chromosomal amplification events across multiple cancers using organoid models and functional assays.

A Single-Cell Tumor Immune Atlas for Precision Oncology

The paper creates a single-cell tumor immune atlas using data from 217 patients and 13 cancer types to improve immune cell annotation and spatial mapping for precision oncology.

Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures

The paper analyzes B cell receptor repertoires from COVID-19 patients to identify convergent immune signatures associated with disease outcome.

IDH-Tau-EGFR triad defines the neovascular landscape of diffuse gliomas by controlling mesenchymal differentiation

This study identifies the IDH-Tau-EGFR triad as a key factor in defining the neovascular landscape of diffuse gliomas by regulating mesenchymal differentiation and vascular microenvironment.

Spatial patterns of species richness and nestedness in ant assemblages along an elevational gradient in a Mediterranean mountain range

The paper examines ant species richness and assemblage composition along elevational gradients in Mediterranean mountains, finding hump-shaped richness patterns and nestedness influenced by environmental stressors.

Subjugation of TGFβ Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End-Joining

This study shows HPV-positive HNSCC cells lose TGFβ signaling, shifting DNA repair from homologous recombination to alternative end-joining, increasing PARP inhibitor sensitivity.