J. Alonso

Glutaredoxin 3 (GLRX3) confers a fusion oncogene-dependent vulnerability to Ewing sarcoma

This study identifies GLRX3 as a vulnerability in Ewing sarcoma driven by EWSR1::FLI1 fusion oncoproteins, showing its role in oxidative stress and iron homeostasis and potential therapeutic targeting.

A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma

This study identifies enasidenib as an effective treatment for IDH2 mutant chondrosarcoma through personalized medicine approaches involving sequencing, cell line models, and in vitro/in vivo testing.

IKK1 kinase coordinates BRD4 and JAK/STAT signaling to subvert DNA damage-based anticancer therapy

This study identifies IKK1's role in coordinating BRD4 and JAK/STAT signaling to resist DNA damage-based therapy in colorectal cancer.

EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism

This study identifies how the EWS::FLI1-DHX9 interaction influences R-loop metabolism and Ewing sarcoma sensitivity to DNA topoisomerase 1 inhibitors.

Single cell transcriptomic analysis of renal allograft rejection reveals novel insights into intragraft TCR clonality

The paper uses single-cell RNA sequencing and TCR sequencing to analyze renal allograft rejection, finding CD8+ T cell clonal expansion linked to rejection, independent of immunosuppression type.

Chromosome 8 gain drives cancer progression by hijacking the translation factor 4E-BP1 sensitizing for targeted CDK4/6 inhibition

This study identifies chr8 gains and 4E-BP1 expression as prognostic markers in Ewing sarcoma, showing they drive cancer progression by promoting proliferation and sensitizing to CDK4/6 inhibitors.

The evolution of two transmissible leukaemias colonizing the coasts of Europe

This study investigates the origin and evolution of two transmissible leukaemias in common cockles, identifying clonal origins, mutational signatures, and genomic instability.

SOX2 expression identifies Ewing sarcoma patients with high risk for tumor relapse and poor survival