Targeting the Schwann Cell EP2/cAMP Nanodomain to Block Pain but not Inflammation
Romina Nassini, Lorenzo Landini, Matilde Marini, Martina Chieca, Daniel Souza Monteiro de Araújo, Marco Montini, Pasquale Pensieri, Vittorio Abruzzese, Gaetano De Siena, Jin Zhang, Elisa Bellantoni, Vincenzo DE GIORGI, Antonia Romitelli, Giulia Brancolini, Raquel Tonello, , Pierangelo Geppetti
The paper identifies a druggable EP2 receptor in Schwann cells that encodes PG-mediated persistent inflammatory pain without affecting protective inflammation.
Nature Communications · Sep 25, 2025Peer-reviewedPharmacology & Toxicology