Qiang Li

MALER: a web server to build, evaluate, and apply machine learning models for numerical biomedical data analysis

Integration of the DD-genome reshapes gene transcription, chromatin architecture and metabolome of allohexaploid wheat leading to enhanced adaptability

This study investigates how integrating the DD genome into tetraploid wheat enhances its adaptability by altering gene transcription, chromatin structure, and metabolome.

Defining biologically directed therapy target signatures in urothelial carcinoma: A transcriptomic framework for precision therapy

This paper identifies biologically distinct transcriptomic and proteomic patterns of ADC and immunotherapy targets in urothelial carcinoma, linking them to histologic and molecular subtypes for precision therapy.

Co-evolution of Oncogenic KRAS Signaling and LILRBhigh Macrophages Drives Pancreatic Cancer Recurrence

This study identifies a co-evolved tumor-immune interaction involving KRAS signaling and LILRBhigh macrophages that drives PDAC recurrence and presents a therapeutic strategy targeting this axis.

METTL3 Uncouples Chromatin Accessibility from Transcription during Retinal Development

This study investigates METTL3's role in retinal development by integrating multi-omics data, revealing its impact on m6A regulation and chromatin accessibility independent of transcription.

Longitudinal analysis of bacterial community dynamics in normal hospital ward following patient occupancy

This study analyzes bacterial community dynamics in a hospital ward after patient occupancy, showing increased alpha diversity on some surfaces and reduced diversity on others, with patient contact significantly influencing microbial composition.

Active DNA demethylation is upstream of rod-photoreceptor fate determination and required for retinal development

The paper shows that DNA demethylation, mediated by TET enzymes, is essential for rod-photoreceptor fate determination during retinal development.