Trypstatin as a Novel TMPRSS2 Inhibitor with Broad-Spectrum 1 Efficacy Against Corona and Influenza Viruses
Jan Lawrenz, Lukas Wettstein, Armando Rodríguez, Rayhane Nchioua, Pascal von Maltitz, Dan Albers, Fabian Zech, Julie Vandeput, Lieve M. J. Naesens, Giorgio Fois, Veronika Neubauer, Nico Preising, Emilia Schmierer, Yasser Almeida‐Hernández, Moritz Petersen, , Jan Münch
This paper identifies Trypstatin, a Kunitz-type protease inhibitor that inhibits TMPRSS2 and related proteases, showing broad-spectrum antiviral activity against SARS-CoV-2, influenza, and other respiratory viruses.
Advanced Science · May 14, 2025Peer-reviewedMicrobiology