F. Ahmad

Natural compound screening predicts novel GSK-3 isoform-specific inhibitors

This study identifies two natural compounds, Psoralidin and Rosmarinic acid, as GSK-3 isoform-specific inhibitors with differential potency against GSK-3 and GSK-3β.

Metabolic and imaging phenotypes associated with RB1 and TP53 loss in prostate cancer

This study investigates metabolic and imaging phenotypes in prostate cancer linked to RB1 and TP53 loss, finding metabolic changes that may inform multimodal imaging strategies.

Technique for rapidly forming networks of microvessel-like structures

This paper presents a method to rapidly form microvessel-like networks using sacrificial alginate structures, enhancing cell survival in restricted environments.

Mathematical Modeling of PCR with Variable Concentrations of DNA and Taq Polymerase

The paper mathematically models and simulates PCR with variable concentrations of DNA and Taq polymerase, finding optimal concentrations that improve PCR product yield.

SARS-CoV-2 infection induces soluble platelet activation markers and PAI-1 in the early moderate stage of COVID-19

This study identifies increased soluble platelet activation markers and PAI-1 in moderate COVID-19, suggesting early coagulation system activation before severe disease.

BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators

This study shows that blocking BCL-XL makes TNBC cells vulnerable to CDK1/2/4 inhibitors, but not other cell cycle regulators, through synergistic effects on survival and apoptosis pathways.

Effect of pesticides and metals on zebrafish embryo development and larval locomotor activity

This study evaluates the predictivity of zebrafish as a toxicology model by testing 24 compounds from two classes on embryo development and larval behavior, finding poor correlation with rodent toxicity data.

Elevated Neurokinin 1-Receptor Expression in uterine products of conception is associated with first trimester Miscarriages

This study examines NK-1R expression in products of conception and finds it is consistently high in miscarriage cases, suggesting its potential role in miscarriage pathophysiology.

Prognostic significance of Substance P/ Neurokinin 1 receptor and its association with hormonal receptors in breast carcinoma

The paper evaluates Substance P and NK-1R expression in breast carcinoma and finds significant association with tumor grade, suggesting potential as a biomarker and therapeutic target.

Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance

This study develops a mouse model of TNBC that recapitulates human tumor heterogeneity and identifies a synergistic combination of WEE1 and BCL-XL inhibition as a potential treatment.

The strength and form of natural selection on transcript abundance in the wild

The paper estimates natural selection on transcript abundance in wild salmonids infected by a parasite, finding upregulated cell cycle genes and disruptive selection linked to survival.

LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1

This study shows that LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1 by regulating cholesterol homeostasis and immune response genes.

Knockdown of PTOV1 and PIN1 Exhibit Common Phenotypic Anti-Cancer Effects in MDA-MB-231 Cells

This study shows that knocking down PTOV1 and PIN1 in breast cancer cells reduces proliferation, migration, and induces apoptosis through shared regulatory mechanisms.

Structural and functional impact of non- synonymous SNPs in the CST complex subunit TEN1: Structural genomics approach

The paper investigates the structural and functional impact of non-synonymous SNPs in the TEN1 gene using computational tools to identify deleterious mutations and their effects on protein stability and function.