Author

A. Schleiffer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1

Frequent Co-Authors

A. Bondarieva· 1 shared A. Dammermann· 1 shared A. Kavirayani· 1 shared A. Toth· 1 shared B. de Massy· 1 shared B. Erdi· 1 shared C. Grey· 1 shared D. Haselbach· 1 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCell Biology

A. Bondarieva

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Author profile →

6 papers

Recent·Most cited

A Phylogenetic Profiling Approach Identifies Novel Ciliogenesis Genes In Drosophila And C. elegans

J. Dobbelaere, T. Y. Su, B. Erdi, A. Schleiffer, A. Dammermann

The paper identifies 386 human genes associated with cilium assembly or motility using phylogenetic profiling in Drosophila and C. elegans, with 70-80% showing ciliary defects.

bioRxiv · Dec 28, 2022 · PreprintCell Biology

Cryo-EM structure of the chain-elongating E3 ligase UBR5

Z. Hodakova, I. Grishkovskaya, H. L. Brunner, D. L. Bolhuis, K. Belacic, A. Schleiffer, H. Kotisch, N. G. Brown, D. Haselbach

The paper presents the cryo-EM structure of UBR5, revealing its dimeric architecture and dynamic domain movements, and identifies AKIRIN2 as an interacting protein.

bioRxiv · Nov 3, 2022 · PreprintBiochemistry

SORORIN is an evolutionary conserved antagonist of WAPL

I. Prusen Mota, M. Galova, A. Schleiffer, T.-t. Nguyentan, I. Kovacikova, T. Nishiyama, J. Gregan, J.-M. Peters, P. Schlogelhofer

This study identifies SORORIN orthologs in yeast and plants, showing they antagonize WAPL to maintain cohesion, with tissue-specific functions in plants.

bioRxiv · Oct 24, 2022 · PreprintCell Biology

Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms

K. Nagasaka, I. F. Davidson, R. Stocsits, W. Tang, G. Wutz, P. Batty, M. Panarotto, G. Litos, A. Schleiffer, D. W. Gerlich, J. M. Peters

This study shows cohesin uses distinct mechanisms for DNA loop extrusion and sister chromatid cohesion, and that CTCF boundary interactions may rely on related mechanisms.

bioRxiv · Sep 23, 2022Cell Biology

Site-specific ubiquitination of the E3 ligase HOIP regulates cell death and immune signaling

L. M. Fennell, L. Deszcz, A. Schleiffer, K. Mechtler, A. Kavirayani, F. Ikeda

This study identifies that site-specific ubiquitination of HOIP at K784 regulates TNF-induced inflammatory signaling and cell fate by modulating TNFR complex formation and LUBAC activity.

bioRxiv · Aug 21, 2019Cell Biology

ANKRD31 regulates spatiotemporal patterning of meiotic recombination initiation and ensures recombination between heterologous sex chromosomes in mice

F. Papanikos, J. A. J. Clement, E. Testa, R. Ravindranathan, C. Grey, I. Dereli, A. Bondarieva, S. Valerio-Cabrera, M. Stanzione, A. Schleiffer, P. Jansa, D. Lustyk, F. Jifeng, J. Forejt, M. Barchi, , A. Toth

This study identifies ANKRD31 as essential for meiotic recombination timing and spatial organization, particularly in sex chromosomes, leading to segregation failure in its absence.

bioRxiv · Sep 28, 2018Cell Biology