Author

F. M. Gribble

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 5 Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 6 Organism:human· 4 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:metabolism & bioenergetics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

F. Reimann· 7 shared R. G. Kay· 3 shared A. Vidal-Puig· 2 shared G. P. Roberts· 2 shared S. O'Rahilly· 2 shared A. E. Adriaenssens· 1 shared A. I. Tarasov· 1 shared A. J. T. Everden· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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7 shared papersPhysiology

F. Reimann

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Longitudinal profiling of the pregnancy plasma proteome through organic solvent precipitation and nano LC-MS/MS

A. L. George, E. Cook, G. C. S. Smith, S. D. Charnock-Jones, S. O'Rahilly, F. Reimann, F. M. Gribble, R. G. Kay

This study profiles the pregnancy plasma proteome using a novel precipitation method, identifying 433 protein groups with tissue-specific associations and changes during gestation.

bioRxiv · Dec 11, 2023 · PreprintBiochemistry

A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion

M. Montaner, J. Denom, V. Simon, W. Jiang, M. K. Holt, D. Brierley, C. Rouch, E. Foppen, N. Kassis, D. Jarriault, D. Khan, L. Eygret, F. Mifsud, D. J. Hodson, J. Broichhagen, , C. Magnan

This study shows that GLP-1 receptor activation in the olfactory bulb enhances insulin secretion via a sympathetic pathway involving the paraventricular nucleus.

bioRxiv · Aug 28, 2023 · PreprintPhysiology

Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice

J. E. Lewis, O. R. Woodward, D. Nuzzaci, C. A. Smith, A. E. Adriaenssens, L. Billing, C. Brighton, B. U. Phillips, J. A. Tadross, S. J. Kinston, E. Ciabatti, B. Gottgens, M. Tripodi, D. Hornigold, D. Baker, , F. Reimann

This study identifies Rxfp4-expressing hypothalamic neurons as regulators of food intake and preference in mice through genetic and pharmacological manipulations.

bioRxiv · Jun 26, 2021Physiology

Antidiabetic drug therapy alleviates type 1 diabetes in mice by promoting pancreatic alpha-cell transdifferentiation

D. Sarnobat, C. R. Moffett, N. Tanday, F. Reimann, F. M. Gribble, P. R. Flatt, A. I. Tarasov

This study shows antidiabetic drugs like liraglutide and dapagliflozin alleviate type 1 diabetes in mice by reducing beta-cell apoptosis and promoting alpha-cell transdifferentiation into beta-cells.

bioRxiv · Aug 3, 2020Physiology

Mass spectrometric characterisation of the circulating peptidome following oral glucose ingestion in control and gastrectomised patients.

R. G. Kay, R. E. Foreman, G. P. Roberts, R. Hardwick, F. Reimann, F. M. Gribble

The paper develops an LC-MS/MS method to measure multiple peptides in plasma after glucose ingestion, showing elevated levels in control and gastrectomized patients.

bioRxiv · Mar 23, 2020Biochemistry

GDF15 and the beneficial actions of metformin in pre-diabetes

A. P. Coll, M. Chen, P. Taskar, D. Rimmington, S. Patel, J. Tadross, I. Cimino, M. Yang, P. Welsh, S. Virtue, D. A. Goldspink, E. Miedzybrodzka, Y. C. L. Tung, S. Rodriguez-Cuenca, R. A. Tomaz, , S. O'Rahilly

This study shows metformin increases GDF15 levels, which is necessary for its weight loss and insulin-sensitizing effects in both humans and mice.

bioRxiv · Jun 21, 2019Physiology

Comparison of human and murine enteroendocrine cells by transcriptomic and peptidomic profiling

G. P. Roberts, P. Larraufie, P. Richards, R. G. Kay, S. G. Galvin, E. L. Miedzybrodzka, A. Leiter, J. H. Li, L. L. Glass, M. K. Ma, B. Lam, G. S. Yeo, R. Scharfmann, D. Chiarugi, R. H. Hardwick, , F. M. Gribble

This study compares human and mouse enteroendocrine cells using transcriptomic and peptidomic profiling to assess mouse as a model for human enteroendocrine function.

bioRxiv · Jul 23, 2018Cell Biology

Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in mice

V. Patel, G. Bidault, J. E. Chambers, S. Carobbio, A. J. T. Everden, C. Garces, L. E. Dalton, F. M. Gribble, A. Vidal-Puig, S. J. Marciniak

This study shows that mice lacking PPP1R15A gain less weight and have improved insulin sensitivity on a high-fat diet but not on standard diet.

bioRxiv · May 4, 2018Physiology