Author

A. Vidal-Puig

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Cell Biology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 7 Research Focus:metabolism & bioenergetics· 5 Research Focus:cell type annotation· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 3

Frequent Co-Authors

S. Carobbio· 3 shared S. Virtue· 3 shared F. M. Gribble· 2 shared G. Bidault· 2 shared L. Vallier· 2 shared M. Yang· 2 shared S. Rodriguez-Cuenca· 2 shared A. Amin· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersPhysiology

S. Carobbio

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Limited oxygen availability in standard cell culture alters metabolism and function in terminally-differentiated cells

J. Tan, S. Virtue, D. M. Norris, O. J. Conway, M. Yang, C. Gribben, F. Lutgu, J. R. Krycer, R. J. Mills, I. Kamzolas, C. Pereira, M. Dale, A. S. Shun-Shion, H. J. Baird, J. A. Horscroft, , D. J. Fazakerley

This study shows that increasing oxygen levels in cell culture improves metabolic function and responsiveness in terminally differentiated cells like adipocytes and hepatocytes.

bioRxiv · Nov 29, 2022 · PreprintCell Biology

Semaphorin 4B is an ADAM17-cleaved inhibitor of adipocyte thermogenesis

A. Amin, M. Badenes, J. Tueshaus, E. de Carvalho, E. Burbridge, P. Faisca, K. Travnickova, A. Barros, S. Carobbio, P. Domingos, A. Vidal-Puig, L. F. Moita, S. Maguire, K. Strisovsky, S. F. Lichtenthaler, C. Adrain

This study identifies SEMA4B as an ADAM17-cleaved inhibitor of adipocyte thermogenesis, showing it dampens thermogenic responses and protects against obesity.

bioRxiv · Oct 11, 2022 · PreprintPhysiology

Paracrine role for endothelial IGF-1 receptor in white adipocyte beiging

N. J. Haywood, K. Bridge, C. Luk, N. Warmke, K. Simmons, M. Drozd, A. Moron, S. Straw, J. Scragg, J. Smith, S. Limumpornpetch, C. Ozber, C. Wilkinson, A. Skromna, N. Makava, , M. Kearney

This study shows that reducing endothelial IGF-1R in nutrient excess promotes white adipocyte beiging, increases energy expenditure, and improves insulin sensitivity through paracrine malonic acid release.

bioRxiv · Dec 1, 2021 · PreprintCell Biology

Time-restricted feeding near dawn entrains long-term behavioral changes through the suprachiasmatic nucleus

Q. Zhai, Y. Zheng, Y. Gu, T. Zhang, B. Yuan, T. Wang, J. Yan, H. Qin, L. Yang, X. Chen, A. Vidal-Puig, Y. Xu

This study shows that time-restricted feeding near dawn alters long-term mouse behavior through SCN GABAergic neurons by affecting exosome-related genes and Kcc2.

bioRxiv · Feb 18, 2021 · PreprintPhysiology

GDF15 and the beneficial actions of metformin in pre-diabetes

A. P. Coll, M. Chen, P. Taskar, D. Rimmington, S. Patel, J. Tadross, I. Cimino, M. Yang, P. Welsh, S. Virtue, D. A. Goldspink, E. Miedzybrodzka, Y. C. L. Tung, S. Rodriguez-Cuenca, R. A. Tomaz, , S. O'Rahilly

This study shows metformin increases GDF15 levels, which is necessary for its weight loss and insulin-sensitizing effects in both humans and mice.

bioRxiv · Jun 21, 2019Physiology

Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity

K. Petkevicius, S. Virtue, G. Bidault, B. Jenkins, C. Cubuk, C. Morgantini, M. Aouadi, J. Dopazo, M. Serlie, A. Koulman, A. Vidal-Puig

This study shows that increased phosphatidylcholine synthesis in macrophages during obesity drives inflammation in adipose tissue, contributing to insulin resistance.

bioRxiv · May 8, 2019Cell Biology

Harnessing natural diversity to identify key amino acid residues in prolidase

H. M. Schilbert, V. Pellegrinelli, S. Rodriguez-Cuenca, A. Vidal-Puig, B. Pucker

The paper identifies conserved amino acid residues in prolidase across species and links them to functional importance and pathogenic potential in human disease.

bioRxiv · Jan 24, 2019 · PreprintEvolutionary Biology

Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in mice

V. Patel, G. Bidault, J. E. Chambers, S. Carobbio, A. J. T. Everden, C. Garces, L. E. Dalton, F. M. Gribble, A. Vidal-Puig, S. J. Marciniak

This study shows that mice lacking PPP1R15A gain less weight and have improved insulin sensitivity on a high-fat diet but not on standard diet.

bioRxiv · May 4, 2018Physiology