S.-Y. Li

In vitro and in vivo validation of cwlM and pbpB essentiality for viability and resistance to imipenem in Mycobacterium abscessus

This study validates cwlM and pbpB as essential genes for Mycobacterium abscessus viability and imipenem resistance using CRISPRi in vitro and in vivo.

Direct inhibitors of InhA with efficacy similar or superior to isoniazid in novel drug regimens for tuberculosis

This study evaluates direct inhibitors of InhA (DIIs) for tuberculosis treatment, showing their efficacy comparable to isoniazid and their potential in new drug regimens.

A perivascular niche supports endometrial epithelial regeneration

This study identifies Nestin+ perivascular cells as contributors to endometrial epithelial regeneration through estrogen-stimulated suppression of Notch signaling.

Hyaluronidase impacts exposures of long-acting injectable paliperidone palmitate in rodent models

This study evaluates how hyaluronidase affects the release and pharmacokinetics of a long-acting injectable drug in mice and rats.

Contezolid can replace linezolid in a novel combination with bedaquiline and pretomanid in a murine model of tuberculosis

The paper evaluates contezolid as a potential replacement for linezolid in combination with bedaquiline and pretomanid in a murine tuberculosis model, finding comparable activity and no cross-resistance.

Subtype-specific circadian clock dysregulation modulates breast cancer biology, invasiveness, and prognosis.

This study identifies subtype-specific circadian clock dysregulation in breast cancer, linking it to EMT, invasiveness, and poorer prognosis.

Using dynamic oral dosing of rifapentine and rifabutin to simulate exposure profiles of long-acting formulations in a mouse model of tuberculosis preventive therapy

Next-generation diarylquinolines improve sterilizing activity of regimens with pretomanid and the novel oxazolidinone TBI-223 in a mouse tuberculosis model

This study evaluates new tuberculosis treatments in mice, finding that replacing bedaquiline with TBAJ-587 reduces relapse, while replacing linezolid with TBI-223 has no significant effect.

Mangroves deviate from other angiosperms in their genome size, leaf cell size, and cell packing density relationships

This study examines how genome size, leaf cell size, and cell packing density relate in mangroves compared to other angiosperms, finding unique adaptations in response to environmental conditions.

GSK2556286 is a novel antitubercular drug candidate effective in vivo with the potential to shorten tuberculosis treatment

Differential in vitro activity of individual drugs and bedaquiline-rifabutin combinations against actively multiplying and nutrient-starved Mycobacterium abscessus

The paper evaluates the in vitro activity of drugs and drug combinations against different growth states of M. abscessus, finding that bedaquiline-rifabutin combinations show potent bactericidal effects.

Mutations in fbiD(Rv2983) as a novel determinant of resistance to pretomanid and delamanid in Mycobacterium tuberculosis

This study identifies mutations in fbiD(Rv2983) as a novel determinant of resistance to pretomanid and delamanid in Mycobacterium tuberculosis through in vitro and in vivo experiments.

Contribution of pretomanid to novel regimens containing bedaquiline with either linezolid or moxifloxacin and pyrazinamide in murine models of tuberculosis

This study shows pretomanid improves the efficacy of TB treatment regimens in mice by reducing relapse and bedaquiline resistance.

Mutations in Rv2983 as a novel determinant of resistance to nitroimidazole drugs in Mycobacterium tuberculosis

This paper identifies Rv2983 as a novel gene conferring resistance to nitroimidazole drugs in Mycobacterium tuberculosis and highlights the challenges in detecting such resistance.

High-dose rifamycins enable shorter oral treatment in a murine model of Mycobacterium ulcerans disease

This study evaluates higher doses of rifamycins in a mouse model of Buruli ulcer, finding dose-dependent efficacy and potential for shorter treatment regimens.

Jagged1/Notch2 Controls Kidney Fibrosis via Tfam-mediated Metabolic Reprogramming

This study identifies Jag1/Notch2 as a key driver of kidney fibrosis through Tfam-mediated metabolic reprogramming in mouse models.