M. E. Mead

A phylogenetic approach to explore the Aspergillus fumigatus conidial surface-associated proteome and its role in pathogenesis

The paper identifies conidial surface proteins in Aspergillus fumigatus and shows their role in immune evasion during infection.

Evolutionary origin, population diversity, and diagnostics for a cryptic hybrid pathogen

This study identifies and characterizes the cryptic fungal pathogen Aspergillus latus, revealing its hybrid origin and developing genomic and phenotypic markers for accurate diagnosis.

COVID-19 Associated Pulmonary Aspergillosis isolates are genomically diverse but similar to each other in their responses to infection-relevant stresses

This study analyzes 11 Aspergillus fumigatus isolates from COVID-19 patients with pulmonary aspergillosis, finding genomic diversity but similar stress responses to infection.

Extensive sequence divergence of non-coding regions between Aspergillus fumigatus, a major fungal pathogen of humans, and its relatives

The paper identifies extensive non-coding sequence divergence in A. fumigatus compared to related species, highlighting its potential role in virulence.

An evolutionary genomic approach reveals both conserved and species-specific genetic elements related to human disease in closely related Aspergillus fungi

This study uses comparative genomics to identify conserved and species-specific genetic elements related to pathogenicity in Aspergillus fungi, revealing evolutionary patterns linked to human disease.

Genomic and phenotypic analysis of COVID-19-associated pulmonary aspergillosis isolates of Aspergillus fumigatus

The paper analyzes the genomes and phenotypes of four Aspergillus fumigatus isolates from COVID-19 patients, finding minor genomic differences and variable virulence traits.

Transcriptomic, protein-DNA interaction, and metabolomic studies of VosA, VelB, and WetA in Aspergillus nidulans asexual spores

The paper investigates the regulatory roles of VosA, VelB, and WetA in asexual spore formation in Aspergillus nidulans using transcriptomic, protein-DNA interaction, and metabolomic analyses.

Recurrent loss of abaA, a master regulator of asexual development in filamentous fungi, correlates with changes in genomic and morphological traits

The paper investigates the loss of abaA, a master regulator of asexual development in fungi, and shows its correlation with morphological changes in asexual fruiting bodies across multiple fungal lineages.

Biosynthetic gene clusters, secondary metabolite profiles, and cards of virulence in the closest nonpathogenic relatives of Aspergillus fumigatus

The paper compares secondary metabolite profiles and biosynthetic gene clusters between the pathogenic Aspergillus fumigatus and its nonpathogenic relatives A. fischeri and A. oerlinghausenensis, identifying conserved and diverged virulence-associated traits.

Genomic and phenotypic heterogeneity of clinical isolates of the human pathogens Aspergillus fumigatus, Aspergillus lentulus and Aspergillus fumigatiaffinis

The paper characterizes the virulence and drug susceptibility of clinical isolates of Aspergillus fumigatus, A. lentulus, and A. fumigatiaffinis, revealing genomic and phenotypic heterogeneity across species and strains.

Gliotoxin, a known virulence factor in the major human pathogen Aspergillus fumigatus, is also biosynthesized by the non-pathogenic relative A. fischeri

This study shows that the non-pathogenic Aspergillus fischeri produces gliotoxin like the pathogenic A. fumigatus, but losing secondary metabolite production does not affect its virulence.

Characterizing the pathogenic, genomic, and chemical traits of Aspergillus fischeri, a close relative of the major human fungal pathogen Aspergillus fumigatus

This study compares Aspergillus fischeri and Aspergillus fumigatus to understand differences in pathogenicity, finding A. fischeri is less virulent, grows slower under stress, and has divergent secondary metabolism.