Author

H. Bastians

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2

Frequent Co-Authors

A. Bufe· 2 shared S. P. Acebron· 2 shared U. Engel· 2 shared Y.-C. Lin· 2 shared A. Ciprianidis· 1 shared A. de Jaime Soguero· 1 shared A. de Jaime-Soguero· 1 shared A. Garcia del Arco· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCell Biology

A. Bufe

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A signalling rheostat controls chromosome segregation fidelity during early lineage specification and neurogenesis by modulating DNA replication stress

A. de Jaime Soguero, J. Hattemer, A. Haas, A. Bufe, B. Di Marco, N. Bohly, J. J. M. Landry, B. Schoell, V. S. Rosa, L. Villacorta, Y. Baskan, S. Androulaki, M. Trapp, V. Benes, B. Das, , S. P. Acebron

The paper identifies a signalling rheostat involving WNT, BMP, and FGF that modulates DNA replication stress and chromosome segregation fidelity during lineage specification and neurogenesis.

bioRxiv · Jul 18, 2023 · PreprintCell Biology

Dormant replication origin firing links replication stress to whole chromosomal instability in human cancer

A.-K. Schmidt, N. Boehly, X. Zhang, B. O. Slusarenko, M. Hennecke, M. Kschischo, H. Bastians

This study shows that increased dormant replication origin firing contributes to whole chromosomal instability in human cancer cells.

bioRxiv · Oct 11, 2021 · PreprintCell Biology

Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis

A. Bufe, A. Garcia del Arco, M.-I. Hennecke, M. Ostermaier, A. de Jaime-Soguero, Y.-C. Lin, A. Ciprianidis, U. Engel, P. Beli, H. Bastians, S. P. Acebron

This paper identifies Wnt signaling's role in mitosis by recruiting KIF2A to the spindle, ensuring chromosome congression and alignment in somatic and pluripotent cells.

bioRxiv · Dec 22, 2020Cell Biology

MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells

H. Gad, O. Mortusewicz, S. G. Rudd, A. Stolz, N. Amaral, L. Brautigam, L. Pudelko, K. Sanjiv, C. Kalderen, A.-S. Jemth, I. Almlof, T. Visnes, N. Schultz, J. Bostrom, J. M. Calderon Montano, , T. Helleday

This study identifies MTH1's role in mitosis and shows that potent MTH1 inhibitors cause mitotic arrest by disrupting tubulin polymerization and suppressing ROS.

bioRxiv · Sep 5, 2019 · PreprintCancer Biology

Altering microtubule dynamics is synergistically toxic with inhibition of the spindle checkpoint

K. M. Schukken, Y.-C. Lin, M. Schubert, S. F. Preuss, J. E. Simon, H. van den Bos, Z. Storchova, H. Bastians, D. C. J. Spierings, F. Foijer

The paper identifies synergistic toxicity between microtubule dynamics alteration and SAC inhibition in aneuploid cells.

bioRxiv · Jul 22, 2019Cancer Biology