Author

C. C.-S. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Organism:virus· 1

Frequent Co-Authors

K.-Y. Yuen· 4 shared S. Yuan· 4 shared V. K.-M. Poon· 4 shared C. C.-Y. Chan· 3 shared H. Chu· 3 shared J. F.-W. Chan· 3 shared K. K.-W. To· 3 shared B. Zhou· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersMicrobiology

K.-Y. Yuen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking

L. Liu, R. G. Casner, Y. Guo, Q. Wang, S. Iketani, J. F.-W. Chan, J. Yu, B. Dadonaite, M. S. Nair, H. Mohri, E. R. Reddem, S. Yuan, V. K.-M. Poon, C. C.-S. Chan, K.-Y. Yuen, , D. D. Ho

This study identifies two antibodies that neutralize all SARS-CoV-2 variants by locking the spike protein in a down conformation, showing a novel mechanism and potential for prophylaxis.

bioRxiv · Apr 8, 2023 · PreprintMicrobiology

The SARS-CoV-2 Omicron (B.1.1.529) variant exhibits altered pathogenicity, transmissibility, and fitness in the golden Syrian hamster model

S. Yuan, Z.-W. Ye, R. Liang, K. Tang, A. J. Zhang, G. Lu, C. P. Ong, V. K.-M. Poon, C. C.-S. Chan, B. W. Y. Mok, Z. Qin, Y. Xie, H. Sun, J. O.-L. Tsang, T. T.-T. Yuen, , J. F. W. Chan

The study compares the pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron and Delta variants in golden Syrian hamsters, finding Omicron less pathogenic but more transmissible and capable of outcompeting Delta under immune pressure.

bioRxiv · Jan 12, 2022 · PreprintMicrobiology

An elite broadly neutralizing antibody protects SARS-CoV-2 Omicron variant challenge

B. Zhou, R. Zhou, J. F.-W. Chan, M. Luo, Q. Peng, S. Yuan, B. W.-Y. Mok, B. Chen, P. Wang, V. K.-M. Poon, H. Chu, C. C.-S. Chan, J. O.-L. Tsang, C. C.-Y. Chan, K.-K. Au, , Z. Chen

This study identifies a broadly neutralizing antibody, ZCB11, effective against SARS-CoV-2 Omicron and Delta variants, showing protection in hamsters.

bioRxiv · Jan 5, 2022 · PreprintImmunology

SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection and injury

B. Zhou, R. Zhou, J. F.-W. Chan, J. Zeng, Q. Zhang, S. Yuan, L. Liu, R. Robinot, S. Shan, J. Ge, H. Y.-H. Kwong, D. Zhou, H. Xu, C. C.-S. Chan, V. K.-M. Poon, , Z. Chen

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

bioRxiv · Oct 5, 2021 · PreprintMicrobiology