H. Tang

The paper identifies public antibody clones in the human repertoire, including virus-neutralizing and anti-PD1 clones, and introduces a tool for analyzing Rep-seq data.

This paper develops a biological activity-based modeling approach to identify novel antiviral compounds against SARS-CoV-2 with high hit rates in live virus assays.

This study identifies aneuploid cancer cells as more vulnerable to spindle assembly checkpoint (SAC) inhibition and explores the underlying mechanisms.

This study shows that immunization with SARS-CoV-2 RBD induces antibodies that neutralize both SARS-CoV-2 and SARS-CoV without causing antibody-dependent enhancement.

The paper shows that IMD/Relish suppresses perilipin1, leading to lipid droplet enlargement that reduces ROS stress during bacterial infection in Drosophila.

The paper develops a sandwich ELISA method using monoclonal antibodies to detect pre-proinsulin in recombinant human insulin production.

The paper identifies the proteasome as critical for ZIKV and DENV replication through three systems biology approaches and finds proteasome inhibitors suppress both viruses.

The paper shows dietary glucose promotes Plasmodium infection by expanding a gut bacterium that alkalizes mosquito midgut, enhancing parasite development.

This paper identifies a dual activity in LanD-like flavoproteins for forming aminovinyl-cysteine residues through oxidative decarboxylation and cyclization of peptides.

This study identifies OsNLP4 as a master regulator of nitrogen use efficiency in rice, showing it improves yield and NUE through transcriptional regulation of nitrogen-related genes.

This study shows that loss of SHMT2 promotes 5-FU resistance in CRC by inducing autophagy through p53 regulation.

This study shows APOC2 promotes colorectal cancer by altering lipid metabolism and activating PHF8 transcription, linking it to poor prognosis.

The paper shows that base-pair substitution rates in E. coli vary symmetrically across the chromosome due to multiple factors affecting replication and repair.

This study shows JNK-IN-8 improves functional recovery in ischemic stroke by reducing neuroinflammation through the JNK/NF-κB pathway.

The paper shows Sec6, an exocyst subunit, localizes to microtubule overlaps before cell plate formation in moss, suggesting it plays a role in vesicle fusion during cytokinesis.

The paper constructs a lung cancer database with gene expression and clinical data from 6,700 patients and develops an open web portal for data exploration and analysis.