H. Zhan

Self-organizing glycolytic waves fuel cell migration and cancer progression

The paper shows that glycolytic waves in the cell cortex drive migration and cancer progression by providing ATP for morphological events and correlating with metastatic potential.

Electrostatic modulation of signaling at cell membrane: Waveform- and time-dependent electric control of ERK dynamics

This study shows that alternating current electric fields can modulate ERK signaling in epithelial cells through waveform- and timing-dependent electrostatic interactions.

Unlocking the Role of Endothelial MPL Receptor and JAK2V617F Mutation: Insights into Cardiovascular Dysfunction in MPNs and CHIP

This study shows that JAK2V617F mutations in endothelial cells cause cardiovascular dysfunction by promoting EndMT, and inhibiting the MPL receptor can prevent this effect.

Deciphering the Differential Impact of Thrombopoietin/MPL Signaling on Hematopoietic Stem Cell Function in Bone Marrow and Spleen

This study examines how TPO/MPL signaling affects HSC function in bone marrow and spleen, finding distinct compensatory mechanisms in splenic niche cells.

Nodavirus RNA Replication Crown Architecture Reveals Proto-Crown Precursor and Viral Protein A Conformational Switching

The paper uses cryo-EM to reveal the structure of nodavirus RNA replication crowns, identifying a proto-crown precursor and conformational changes in viral protein A.

Mitochondrial Genome Analysis and Phylogeny and Divergence Time Evaluation of the Strix aluco

This study reports the first complete mitochondrial genome of Strix aluco, identifies its divergence time, and links geographic and climatic factors to its speciation.

A murine model with JAK2V617F expression in both hematopoietic cells and vascular endothelial cells recapitulates the key features of human myeloproliferative neoplasm

This study creates a murine model with JAK2V617F in both hematopoietic and vascular cells, showing it mimics human MPN features like disease progression and cardiovascular issues.

Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm

JAK2V617F mutant megakaryocytes contribute to hematopoietic aging in a murine model of myeloproliferative neoplasm

This study shows that JAK2V617F mutant megakaryocytes accelerate hematopoietic aging by affecting HSC interactions and vascular niche function in a murine MPN model.

Cell competition between wild-type and JAK2V617F mutant cells in a murine model of a myeloproliferative neoplasm

This study shows that wild-type cells alter JAK2V617F mutant cell behavior, and a mutant microenvironment enables mutant clonal expansion in MPN.

Global reinforcement of DNA methylation through enhancement of RNA-directed DNA methylation ensures sexual reproduction in rice

This study shows that enhanced RNA-directed DNA methylation (RdDM) in reproductive organs increases DNA methylation, ensuring sexual reproduction in rice by regulating gene expression.

PDIP38 is a novel adaptor-like modulator of the mitochondrial AAA+ protease CLPXP

This paper identifies PDIP38 as a mitochondrial adaptor protein that interacts with CLPX and modulates the CLPXP protease function by stabilizing CLPX and facilitating substrate recognition.