Felipe Saceanu Leser

The Nuclear-Cytoskeletal Interface Is a Vulnerability in Aging Endothelium

This study identifies the nuclear-cytoskeletal interface as a vulnerability in aging endothelium, showing that Progerin disrupts this interface and impairs angiogenesis and lumen formation.

RIG-I RNA agonist activates immunostimulatory macrophages to enhance checkpoint immunotherapy for glioblastoma

The paper shows that activating RIG-I in macrophages enhances immunotherapy for glioblastoma by repolarizing tumor-associated macrophages and boosting anti-tumor immune responses.

Estimating the replicability of Brazilian biomedical science

In validated multicenter replications, 20 to 44% of 45 published Brazilian MTT, RT-PCR and elevated plus maze experiments replicated, depending on criterion; replication effects were usually smaller.