Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments
Sarah M Chang, Muhammad Bin Munim, S Trojan, Huel Cox, Anna Shevzov-Zebrun, Keene L. Abbott, Renee Chang, Matthew G. Vander Heiden
The paper shows cancer cells adjust mitochondrial respiration to alter NAD+/NADH ratios, enhancing biomass synthesis and proliferation under nutrient limitation.
bioRxiv · May 9, 2025 · PreprintCancer Biology