Author

G. Dubin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

A. Czarna· 4 shared A. Matsuda· 3 shared K. Pyrc· 3 shared M. Pachota· 3 shared A. Karim· 2 shared A. Mourao· 2 shared G. Popowicz· 2 shared J. Plewka· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersMicrobiology

A. Czarna

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structure of Trypanosoma peroxisomal import complex unveils conformational dynamics

R. R. Sonani, A. Blat, M. R. Jemiola-Rzeminska, O. Lipinski, S. N. Patel, T. Sood, G. Dubin

The paper determines the cryo-EM structure of a Trypanosoma cruzi peroxisomal import ternary complex and identifies conformational dynamics at key interfaces.

bioRxiv · Apr 3, 2023Biochemistry

Structural perspective on the design of selective DYRK1B inhibitors

P. Grygier, K. Pustelny, F. Menezes, M. Jemiola-Rzeminska, P. Suder, G. Dubin, A. Czarna

The paper determines the crystal structures of DYRK1B and DYRK1A in complex with AZ191, identifying structural differences that inform selective inhibitor design.

bioRxiv · Dec 23, 2022Biochemistry

Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity.

A. Czarna, J. Plewka, L. Kresik, A. Matsuda, A. Karim, C. Robinson, S. O Byrne, F. Cunningham, I. Georgiou, M. Pachota, G. Popowicz, P. G. Wyatt, G. Dubin, K. Pyrc

The paper presents the crystal structure of SARS-CoV-2 nsp14 in apo-form and explains how nsp10 modulates its exonuclease activity through structural changes.

Structure · Aug 1, 2022Peer-reviewedMicrobiology

Despite the odds: formation of the SARS-CoV-2 methylation complex.

A. Matsuda, J. Plewka, Y. Chykunova, A. N. Jones, M. Pachota, M. Rawski, A. Mourao, A. Karim, L. Kresik, K. Lis, I. Minia, K. Hartman, R. Sonani, G. Dubin, M. Sattler, , A. Czarna

This study demonstrates that SARS-CoV-2 proteins nsp14, nsp10, and nsp16 form a heterotrimer complex, which modulates nsp14's exonuclease activity and protects viral RNA.

bioRxiv · Jan 25, 2022Microbiology

Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 and other betacoronaviruses

V. Napolitano, A. Dabrowska, K. Schorpp, A. Mourao, E. Barreto-Duran, M. Benedyk, P. Botwina, S. Brandner, M. Bostock, Y. Chykunova, A. Czarna, G. Dubin, T. Frohlich, M. Hoelscher, M. Jedrysik, , K. Pyrc

This study identifies acriflavine as a potent inhibitor of SARS-CoV-2 and other betacoronaviruses, effective in cellular models, in vivo, and ex vivo.

bioRxiv · Mar 20, 2021Microbiology

Kallikrein-related peptidase 14 activates zymogens of membrane type matrix metalloproteinases (MT-MMPs) - a CleavEx library-based analysis

K. Falkowski, E. Bielecka, I. B. Thogersen, O. Bochenska, K. Płaza, M. Kalinska, L. Sasiadek, M. Magoch, A. Pecak, M. Wisniewska, N. Gruba, M. Wysocka, A. Wojtysiak, M. Brzezinska-Bodal, K. Sychowska, , T. Kantyka

This study identifies KLK14 as a specific activator of proMT-MMPs using a CleavEx library-based approach, revealing its role in ECM remodeling and potential implications in cancer.

bioRxiv · Apr 23, 2020Biochemistry