Endocytic adaptor AP-2 maintains Purkinje cell function by balancing cerebellar parallel and climbing fiber synapses
Marianna Tolve, Janine Tutas, Ebru Ozer, Ines Klein, Anne Petzold, Veronika J. Fritz, Melina Overhoff, Quinn Silverman, Ellie Koletsou, Filip Liebsch, Günter Schwarz, Tatiana M. Korotkova, Silvana Valtcheva, Graziana Gatto, Natalia L. Kononenko
This study shows that AP-2 maintains Purkinje cell function by balancing synaptic inputs from parallel and climbing fibers, preventing degeneration and motor dysfunction.
Cell Reports · Feb 1, 2025Peer-reviewedNeuroscience