Author

K. J. Else

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 4 Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 7 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 3 Organism:C. elegans· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

R. Forman· 6 shared A. J. Russell· 4 shared D. B. Sattelle· 4 shared F. A. Partridge· 4 shared G. M. Wynne· 3 shared N. J. Willis· 3 shared A. E. Brown· 2 shared C. J. Bataille· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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6 shared papersPharmacology & Toxicology

R. Forman

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The adaptive immune response to Trichuris in wild versus laboratory mice: An established model system in context

I. Mair, J. Fenn, A. Wolfenden, A. Lowe, A. Bennett, A. Muir, J. Thompson, O. Dieumerci, L. Logunova, S. Shultz, K. J. Else, J. E. Bradley

The paper compares immune responses to Trichuris muris in wild and laboratory mice, finding quantitative differences and age-specific effects in cytokine production and Th1/Th2 balance.

bioRxiv · Aug 28, 2023 · PreprintImmunology

Mmp17-deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection

P. M. Vornewald, R. Forman, R. Yao, N. Parmar, H. T. Lindholm, M. Martin-Alonso, K. J. Else, M. J. Oudhoff

This study shows that Mmp17-deficient mice have increased goblet cell effector genes and resistance to Trichuris muris infection without changes in traditional immune modulators.

bioRxiv · Jul 10, 2023Immunology

Screening the Medicines for Malaria Pandemic Response Box chemical library on Caenorhabditis elegans identifies re-profiled candidate anthelmintic drug leads

M. Nick, F. A. Partridge, R. Forman, C. J. R. Bataille, K. J. Else, A. J. Russell, D. B. Sattelle

The paper screens a chemical library on C. elegans to identify potential anthelmintic drug leads effective against parasitic nematodes.

bioRxiv · Aug 10, 2022 · PreprintPharmacology & Toxicology

Structural requirements for dihydrobenzoxazepinone anthelmintics: actions against medically important and model parasites - Trichuris muris, Brugia malayi, Heligmosomoides polygyrus and Schistosoma mansoni

F. A. Partridge, C. J. Bataille, R. Forman, A. E. Marriott, J. Forde-Thomas, C. Häberli, R. L. Dinsdale, J. D. O'Sullivan, N. J. Willis, G. M. Wynne, H. Whiteland, J. Archer, A. Steven, J. D. Turner, J. Keiser, , D. B. Sattelle

The paper investigates the structure-activity relationship of dihydrobenzoxazepinone (DHB) compounds against various parasitic nematodes and trematodes, identifying key structural features for anthelmintic activity.

ACS Infectious Diseases · Apr 2, 2021Peer-reviewedPharmacology & Toxicology

Morphological variability in the mucosal attachment site of Trichuris muris revealed by X-ray microcomputed tomography

J. O'Sullivan, S. M. Cruickshank, P. Withers, K. J. Else

This paper uses X-ray microCT to reveal morphological variability in Trichuris muris attachment sites, showing tunnel structures that contact host immune compartments and vary in length and integrity.

bioRxiv · Jan 7, 2021Microbiology

Cell-intrinsic IL4R alpha independence of large intestinal RELMα+ Ym1+ macrophages

R. Forman, L. B. Logunova, H. Smith, K. Wenyss, I. Mair, L. Boon, J. E. Allen, W. Müller, J. L. Pennock, K. J. Else

This study shows that RELMα+ Ym1+ macrophages in the large intestine can upregulate these markers without IL4R signaling, challenging the idea that IL4/IL13 is required for their activation.

bioRxiv · Dec 17, 2020Immunology

2,4-Diaminothienopyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm

F. A. Partridge, R. Forman, N. J. Willis, C. J. Bataille, E. A. Murphy, A. E. Brown, N. Heyer-Chauhan, B. Marinic, D. J. Sowood, G. M. Wynne, K. J. Else, A. J. Russell, D. B. Sattelle

This paper identifies a new class of anthelmintic compounds, DATPs, effective against whipworm adult and egg stages, suggesting potential for environmental control strategies.

bioRxiv · Apr 26, 2018Pharmacology & Toxicology

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes

F. A. Partridge, A. E. Brown, S. D. Buckingham, N. J. Willis, G. M. Wynne, R. Forman, K. J. Else, A. A. Morrison, J. B. Matthews, A. J. Russell, D. A. Lomas, D. B. Sattelle

The paper develops an automated system for screening chemical libraries against nematodes, identifying known and novel anthelmintic compounds.

bioRxiv · Sep 11, 2017Pharmacology & Toxicology