Author

J. Hanna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Evolutionary Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Research Focus:ecology & biodiversity· 1

Frequent Co-Authors

A. Shelke· 1 shared B. A. Schulman· 1 shared C. Chilamakuri· 1 shared C. Grady· 1 shared C. Kapeni· 1 shared C. Levine· 1 shared D. A. Petrov· 1 shared D. Alland· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperMicrobiology

A. Shelke

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Visualizing chaperone-mediated multistep assembly of the human 20S proteasome

F. Adolf, J. Du, E. A. Goodall, R. M. Walsh, S. rawson, S. von Gronaua, J. W. Harper, J. Hanna, B. A. Schulman

The paper uses cryo-EM to visualize the assembly of the human 20S proteasome, revealing how chaperones and propeptides guide subunit incorporation and proteasome activation.

bioRxiv · Jan 27, 2024Biochemistry

Development of amidase-dependent pyrazinoic acid prodrugs with activity against pyrazinamide resistant Mycobacterium tuberculosis

C. Levine, R. Jadhav, P. Yan, K. Tsotetsi, X. Wang, D. Awasthi, C. Grady, A. Shelke, S. S. Daher, T. Richmann, R. Shrestha, P. Sukheja, J. Patel, P. R. Barnett, R. J. Dikdan, , P. Kumar

This paper develops amidase-dependent pyrazinoic acid prodrugs that bypass PncA activation, showing efficacy against PZA-resistant Mtb.

bioRxiv · Jul 5, 2022 · PreprintMicrobiology

Direct observation of adaptive tracking on ecological timescales in Drosophila

S. M. Rudman, S. I. Greenblum, S. Rajpurohit, N. J. Betancourt, J. Hanna, S. Tilk, T. Yokoyama, D. A. Petrov, P. Schmidt

The paper tracks phenotypic and genomic adaptation in Drosophila over ten generations, showing rapid and dynamic responses to environmental change.

bioRxiv · Apr 27, 2021 · PreprintEvolutionary Biology

Non-canonical Hedgehog signaling through L-type voltage gated Ca2+ channels controls CD8+ T cell killing

J. Hanna, C. Kapeni, L. O'Brien, V. Carbonaro, F. Beke, C. Chilamakuri, M. de la Roche

This study identifies L-type voltage gated Ca2+ channels as essential for Hedgehog signaling in CD8+ T cells, which is critical for their cytotoxic function.

bioRxiv · Mar 1, 2021 · PreprintImmunology