Author

J. L. Kopp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cancer & tumor microenvironment· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. F. Schaeffer· 4 shared A. M. Zhang· 2 shared J. D. Johnson· 2 shared T. J. J. de Winter· 2 shared X. Hu· 2 shared A. Huang· 1 shared A. M. Y. Zhang· 1 shared A. Ramzy· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersCancer Biology

D. F. Schaeffer

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Author profile →

5 papers

Recent·Most cited

Acvr1b loss increases formation of pancreatic precancerous lesions from acinar and ductal cells of origin

K. Saeki, I. S. Wood, W. C. K. Wang, S. Patil, Y. Sun, D. F. Schaeffer, G. H. Su, J. L. Kopp

This study shows that Acvr1b loss in combination with Kras mutation promotes precancerous lesions from both acinar and ductal cells in the pancreas, but the IPMN-like phenotype differs when mutations occur in all cells.

bioRxiv · Jun 8, 2023 · PreprintCancer Biology

Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics

A. M. Zhang, T. J. J. de Winter, S. Wang, S. Flibotte, Y. B. Zhao, X. Hu, H. Li, D. F. Schaeffer, J. D. Johnson, J. L. Kopp

This study uses single-cell transcriptomics to show hyperinsulinemia affects pancreatic cancer development and immune microenvironment by altering immune cell pathways and reducing pre-cancerous lesions.

bioRxiv · Mar 10, 2021Cancer Biology

PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response

J. Ye, A. Huang, H. Wang, A. M. Y. Zhang, X. Huang, Q. Lan, T. Sato, S. Goyama, M. Kurokawa, C. Deng, M. Sander, D. F. Schaeffer, W. Li, J. L. Kopp, R. Xie

This study shows PRDM3 suppresses pancreatitis and pancreatic tumorigenesis by modulating inflammation and Kras-driven oncogenesis in acinar cells.

bioRxiv · Dec 18, 2019Cancer Biology

Pancreas-specific miR-216a regulates proliferation and endocrine and exocrine cell function in vivo

S. Erener, C. E. Ellis, A. Ramzy, M. M. Glavas, S. O'Dwyer, S. Pereira, T. Wang, J. Pang, J. E. Bruin, M. J. Riedel, R. J. Baker, T. D. Webber, J. L. Kopp, S. Herzig, T. J. Kieffer

This study identifies miR-216a as a pancreas-specific miRNA that regulates cell proliferation and function in both endocrine and exocrine cells, with implications for diabetes and pancreatic cancer.

bioRxiv · Oct 7, 2019 · PreprintPhysiology

Endogenous insulin contributes to pancreatic cancer development

A. M. Zhang, J. Magrill, T. J. J. de Winter, X. Hu, S. Skovso, D. F. Schaeffer, J. L. Kopp, J. D. Johnson

This study shows that reducing endogenous insulin production decreases pancreatic cancer precursors in mice, suggesting insulin hypersecretion contributes to pancreatic cancer development.

bioRxiv · Jan 24, 2019 · PreprintCancer Biology